浸润性鳞状细胞癌，位于周缘性掌皮下角化不全的斑块内。

IF 1.6 4区医学 Q3 DERMATOLOGY

Journal of Cutaneous Pathology Pub Date : 2024-06-08 DOI:10.1111/cup.14670

Luis Araya MD, Celia Horcajada MD, Amalia Moreno MD, Jesús M. Borbujo MD, PhD, Juan C. Tardío MD, PhD

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引用次数: 0

摘要

环状手掌角化过度症（CPH）是一种局部表皮角化障碍性疾病，表现为手掌或足底出现局限性、凹陷的红斑。其组织病理学特征是角膜表皮层突然变薄。CPH 被认为是一种良性病变，但也有少数病例在角化不全的表皮层出现了发育不良的变化/原位癌。我们在此报告一例在 CPH 斑块内发生浸润性鳞状细胞癌的病例。这种疾病恶变的发病机制仍有待明确。临床医生应认识到 CPH 发生恶变的可能性，并对这种疾病进行更密切的随访。

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Invasive squamous cell carcinoma within a plaque of circumscribed palmar hypokeratosis

Circumscribed palmar hypokeratosis (CPH) is a localized disorder of epidermal keratinization that is presented as a well-delimited, depressed, erythematous plaque on the palms or on the soles. It is histopathologically characterized by an abrupt thinning of the corneal epidermal layer. CPH is considered a benign condition, but a few cases with dysplastic changes/carcinoma in situ in the hypokeratotic epidermis have been described. We report hereby a case of invasive squamous cell carcinoma developed within a plaque of CPH. The pathogenesis of the malignant changes in this disorder remains to be clarified. Clinicians should be aware of the potential for developing malignancy in CPH and carry out a closer follow-up of this disorder.

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来源期刊

Journal of Cutaneous Pathology 医学-病理学

CiteScore

3.20

自引率

5.90%

发文量

174

审稿时长

3-8 weeks

期刊介绍： Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.