Zicheng Zhang , Wenfeng Wu , Meng Li , Longbo Du , Jiantao Li , Xin Yin , Wei Zhang
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引用次数: 0
摘要
肌肉骨骼系统涉及多种细胞类型,它们参与维持骨平衡,这对平衡成骨和破骨细胞生成至关重要。骨平衡失调可导致多种肌肉骨骼疾病,包括骨关节炎(OA)和骨质疏松症(OP)。近年来,由于骨免疫对骨稳态的重要调节作用,人们对骨免疫的兴趣与日俱增。包括巨噬细胞、T 细胞和 B 细胞在内的各种细胞类型参与骨免疫学并调节骨平衡。目前,细胞外囊泡(EVs)在细胞间通讯中发挥着至关重要的作用。尤其是间充质干细胞(MSC)衍生的EVs已被报道为某些免疫相关疾病的潜在免疫调节因子。本综述旨在介绍间充质干细胞衍生的EVs在肌肉骨骼疾病中的免疫调节作用的最新进展。此外,我们还讨论了间充质干细胞-EVs 对成骨细胞、破骨细胞和软骨细胞中程序性细胞死亡的免疫调节作用,以及这种调节作用对骨稳态的影响。此外,我们还深入探讨了间充质干细胞-EVs在治疗常见肌肉骨骼疾病(包括OP、OA和骨折)中的潜在应用。总之,这篇综述强调了基于间充质干细胞-EV 的肌肉骨骼疾病疗法目前的研究进展和未来方向。
Mesenchymal stem cell–derived extracellular vesicles: A novel nanoimmunoregulatory tool in musculoskeletal diseases
The musculoskeletal system involves various cell types that participate in maintaining bone homeostasis, which is crucial for balancing osteogenesis and osteoclastogenesis. Imbalances in bone homeostasis can lead to numerous musculoskeletal disorders, including osteoarthritis (OA) and osteoporosis (OP). In recent years, there has been growing interest in osteoimmunity due to its significant regulatory impact on bone homeostasis. Various cell types, including macrophages, T cells, and B cells, participate in osteoimmunology and regulate bone homeostasis. Currently, extracellular vesicles (EVs) play crucial roles in cell-to-cell communication. In particular, mesenchymal stem cell (MSC)-derived EVs have been reported as potential immunoregulators in certain immune-related diseases. This comprehensive review aims to present recent advancements in the understanding of the immunoregulatory effects of MSC-derived EVs in musculoskeletal diseases. In addition, we discuss the immunoregulatory effects of MSC-EVs on programed cell death in osteoblasts, osteoclasts, and chondrocytes, and the effect of this modulation on bone homeostasis. Moreover, we provide insights into the potential applications of MSC-EVs in the management of prevalent musculoskeletal disorders, including OP, OA, and bone fractures. In conclusion, this review emphasizes current advancements in research and future directions in MSC-EV-based therapies for musculoskeletal disorders.
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.