糖尿病与腹主动脉瘤:对 AAA 的保护作用是单单由于抗糖尿病药物、单单由于疾病,还是两者兼而有之?

Archives of internal medicine research Pub Date : 2024-01-01 Epub Date: 2024-05-09 DOI:10.26502/aimr.0169
Gaithrri Shanmuganathan, Devendra K Agrawal
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引用次数: 0

摘要

糖尿病是一种代谢性疾病,可导致多种微血管和大血管疾病。有趣的是,许多研究表明,糖尿病与腹主动脉瘤(AAA)的发生和扩大之间存在反向关系。一种假设认为,高血糖和高级糖化终产物导致的主动脉壁僵硬可延缓 AAA 的发展和生长。其他研究提出,同时使用抗糖尿病药物可促进抗炎细胞因子,同时抑制促炎细胞因子,这可能是糖尿病对 AAA 产生保护作用的原因。与此相反,研究发现糖尿病会对 AAA 修复后的结果产生负面影响,这可能是由于血糖升高对愈合过程产生了负面影响。目前的文献也证明了使用氟喹诺酮类药物对 AAA 的负面影响。这篇综合综述批判性地回顾和总结了糖尿病、抗糖尿病药物和氟喹诺酮类药物对 AAA 的作用,以及糖尿病和某些抗糖尿病药物对 AAA 修复后疗效的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diabetes and Abdominal Aortic Aneurysm: Is the Protective Effect on AAA Due to Antidiabetic Medications Alone, Due to the Disease Alone, or Both?

Diabetes is a metabolic disease that may result in multiple microvascular and macrovascular diseases. Interestingly, many studies have demonstrated the inverse relationship between diabetes and the development and expansion of abdominal aortic aneurysm (AAA). One hypothesis is that the aortic wall stiffness resulting from hyperglycemia and advanced glycation end products could delay the development and growth of AAA. Other studies have proposed that the concurrent use of antidiabetic medications which promote anti-inflammatory cytokines while hindering pro-inflammatory cytokines may potentially be the reason for this protective effect of diabetes on AAA. Contrastingly, the presence of diabetes has been found to have a negative effect on the outcome of AAA following its repair which may be due to elevated blood glucose negatively affecting the healing process. The current literature has also demonstrated the negative impact of the use of fluoroquinolones on AAA. This comprehensive review critically reviewed and summarized the role of diabetes, anti-diabetes medications and fluoroquinolones on AAA, and on the effect of diabetes and certain anti-diabetes medications on outcomes following its repair.

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