肝脏线粒体偶联效率及其与氧化能力和腺嘌呤核苷酸转运酶含量的关系：鳄鱼、鸟类和哺乳动物的比较研究。

IF 3.9 3区生物学 Q2 CELL BIOLOGY

Mitochondrion Pub Date : 2024-06-04 DOI:10.1016/j.mito.2024.101909

Damien Roussel , Nathan Roussel , Yann Voituron , Benjamin Rey

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引用次数: 0

摘要

本研究的主要目的是评估腺嘌呤核苷酸转位酶（ANT）含量是否与大鼠、鳄鱼和鸭子肝脏线粒体中线粒体耦合效率的系统发育差异有关。我们的测量包括线粒体膜电导率、ANT含量和各种稳态速率下的氧化磷酸化通量。我们观察到这三个物种的肝脏线粒体耦合效率存在明显差异。这些差异与线粒体氧化能力的种间差异有关，其次与肝脏线粒体的ANT含量有关。这些发现拓展了之前的研究，强调了氧化能力和ANT在调节种间线粒体效率中的关键作用。

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Liver mitochondrial coupling efficiency and its relationship to oxidative capacity and adenine nucleotide translocase content: A comparative study among crocodiles, birds and mammals

The primary objective of this study was to assess whether adenine nucleotide translocase (ANT) content could be associated with phylogenetic disparities in mitochondrial coupling efficiency, within liver mitochondria obtained from rats, crocodiles, and ducklings. Our measurements included mitochondrial membrane conductance, ANT content, and oxidative phosphorylation fluxes at various steady-state rates. We observed significant variations in liver mitochondrial coupling efficiency across the three species. These variations correlated with interspecific differences in mitochondrial oxidative capacity and, to a lesser extent, the ANT content of liver mitochondria. These findings expand upon previous research by highlighting the pivotal role of oxidative capacity and ANT in modulating mitochondrial efficiency on an interspecific scale.

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来源期刊

Mitochondrion 生物-细胞生物学

CiteScore

9.40

自引率

4.50%

发文量

审稿时长

13.6 weeks

期刊介绍： Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.