对国际研究人员关于治疗肩袖损伤的生物活性药物的论文中的关键词进行聚类分析和可视化处理

N. V. Vasil’chenko, A. A. Vetoshkin, S. S. Gusev
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Therefore, biologic augmentation may be a promising strategy for promoting tissue healing.The objective of this study is to perform a cluster analysis and visualization of keywords in papers by international researchers on innovative rotator cuff injury treatments, including bioactive drug therapy.Methods. This study investigated publications dated 2013 to 2022 and published in the PubMed international reference and bibliographic database, using terminology-based search queries, i.e. (concentrated bone marrow aspirate OR stem cells OR platelet) and (rotator cuff injury). The search yielded 484 relevant scientific papers. Relevant bibliographic information was uploaded in “.txt” format into the VOSviewer 1.6.20 analytical software.Results and analysis. . With the coefficient of determination (R2 = 0.94), the polynomial trend of article dynamics showed an increase in the number of publications. The average annual number of articles was 46. 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引用次数: 0

摘要

相关性。肩袖断裂的发病率居高不下,且没有减少的迹象。尽管在先进诊断和手术治疗方面拥有丰富的专业知识,并有大量科学证据支持,但实现最佳临床疗效仍是一项挑战。因此,研究人员和临床医生一直在探索其他方法来改善治疗效果。最近的骨科研究表明,使用生物活性药物(生物增量),特别是多潜能干细胞,可对组织再生产生积极影响。本研究旨在对国际研究人员发表的有关肩袖损伤创新疗法(包括生物活性药物疗法)的论文中的关键词进行聚类分析和可视化。本研究调查了2013年至2022年发表在PubMed国际参考文献和书目数据库中的论文,使用了基于术语的搜索查询,即(浓缩骨髓抽吸液或干细胞或血小板)和(肩袖损伤)。搜索结果为 484 篇相关科学论文。相关文献信息以".txt "格式上传至 VOSviewer 1.6.20 分析软件。.根据判定系数(R2 = 0.94),文章动态的多项式趋势显示论文数量在增加。年均文章数量为 46 篇。通过 3 次重复,对 207 个关键词进行了分析,随后将其合并为 7 个群组。第 1 组名为 "肩袖损伤的关节镜治疗结果"。它包含 21.1 % 的论文,关键词的总链接强度为 22.5 %。第 2 组 "富血小板血浆在肩袖损伤和疾病中的应用 "包含 24.2 % 的论文,总链接强度为 21.2 %。第 3 组 "生物模型 "分别占 18.6% 和 20.0%。第4组 "间充质干细胞的再生潜力 "分别占15.2%和15.4%;第5组 "利用间充质干细胞治疗肩袖损伤 "分别占11.7%和11.2%;第6组 "间充质干细胞治疗肩袖损伤的效率 "分别占8.6%和8.6%;第7组 "生物活性药物在骨科/骨生物学中的应用 "分别占1.4%和1.1%。此外,还确定了主要作者和研究学校。研究结果有助于深入了解过去 10 年的研究领域,从而为科学家和从业人员探索肩袖损伤的创新治疗方法(包括使用生物活性药物)提供了信息支持。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cluster analysis and visualization of keywords in papers by international researchers on bioactive drugs in the treatment of rotator cuff injuries
Relevance. Rotator cuff ruptures continue to show high incidence with no signs of decrease. Despite the available expertise in advanced diagnosis and surgical treatment, supported by extensive scientific evidence, achieving optimal clinical outcomes remains a challenge. As a result, researchers and clinicians have been exploring alternative methods to improve outcomes. Recent studies in orthopedics have demonstrated that using bioactive drugs (biologic augmentation), particularly multipotent stem cells, may positively influence tissue regeneration. Therefore, biologic augmentation may be a promising strategy for promoting tissue healing.The objective of this study is to perform a cluster analysis and visualization of keywords in papers by international researchers on innovative rotator cuff injury treatments, including bioactive drug therapy.Methods. This study investigated publications dated 2013 to 2022 and published in the PubMed international reference and bibliographic database, using terminology-based search queries, i.e. (concentrated bone marrow aspirate OR stem cells OR platelet) and (rotator cuff injury). The search yielded 484 relevant scientific papers. Relevant bibliographic information was uploaded in “.txt” format into the VOSviewer 1.6.20 analytical software.Results and analysis. . With the coefficient of determination (R2 = 0.94), the polynomial trend of article dynamics showed an increase in the number of publications. The average annual number of articles was 46. With 3 repetitions, 207 keywords were analyzed and combined subsequently into 7 clusters. Cluster 1 was called ‘Arthroscopy treatment results of rotator cuff injuries’. It contained 21.1 % of papers with the total link strength of keywords 22.5 %. Cluster 2 ‘Use of platelet-rich plasma in injuries and diseases of the rotator cuff’ contained 24.2 % of papers with the total link strength 21.2 %. Cluster 3 ‘Biological models’ yielded 18.6 % and 20.0 % respectively. Cluster 4 ‘Regenerative potential of mesenchymal stem cells – 15.2 % and 15.4 % respectively; Cluster 5 ‘Using mesenchymal stem cells in rotator cuff injury treatment’ – 11.7 % and 11.2 % respectively; Cluster 6 ‘Efficiency of mesenchymal stem cells on the treatment of rotator cuff injuries’ – 8.6 % and 8.6 % respectively; Cluster 7 ‘Using of bioactive drugs in orthopaedics / orthobiology’ – 1.4 % and 1.1 % respectively. Leading authors and research schools were identified as well.Conclusion. The results provided an insight into the areas of research over the past 10 years and hence have provided information support for scientists and practitioners exploring innovative treatments for rotator cuff injuries, including the use of bioactive drugs.
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