断裂的链，破碎的心：探索 DNA 损伤与神经变性之间的联系

IF 3 3区生物学 Q2 GENETICS & HEREDITY

DNA Repair Pub Date : 2024-06-03 DOI:10.1016/j.dnarep.2024.103699

Ioanna Stavgiannoudaki , Evi Goulielmaki , George A. Garinis

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引用次数: 0

摘要

神经退行性疾病的主要特征是神经元逐渐丧失，导致认知能力下降，并表现出无法治愈和使人衰弱的病症，如阿尔茨海默氏症、帕金森氏症和亨廷顿氏症。越来越多的人类综合征和携带 DNA 修复先天缺陷的小鼠过早出现了神经退行性病变特征，这说明基因组维护的缺失是导致与年龄相关的神经退行性病变的原因之一。在此，我们将讨论持续性 DNA 损伤、关键 DNA 修复机制和基因组完整性受损在与年龄相关的神经退行性病变中的相关性，强调研究这些联系的重要性，以便为制定合理的干预策略铺平道路，从而延缓神经退行性病变的发生并促进健康老龄化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Broken strands, broken minds: Exploring the nexus of DNA damage and neurodegeneration

Neurodegenerative disorders are primarily characterized by neuron loss progressively leading to cognitive decline and the manifestation of incurable and debilitating conditions, such as Alzheimer's, Parkinson's, and Huntington's diseases. Loss of genome maintenance causally contributes to age-related neurodegeneration, as exemplified by the premature appearance of neurodegenerative features in a growing family of human syndromes and mice harbouring inborn defects in DNA repair. Here, we discuss the relevance of persistent DNA damage, key DNA repair mechanisms and compromised genome integrity in age-related neurodegeneration highlighting the significance of investigating these connections to pave the way for the development of rationalized intervention strategies aimed at delaying the onset of neurodegenerative disorders and promoting healthy aging.

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来源期刊

DNA Repair 生物-毒理学

CiteScore

7.60

自引率

5.30%

发文量

审稿时长

59 days

期刊介绍： DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease. DNA Repair publishes full-length research articles, brief reports on research, and reviews. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports also will be considered for publication.