用植物乳杆菌 JBMI F5 发酵的黑莓通过抑制脂肪生成信号机制抗肥胖的特性

Jae Young Park, Ha-Rim Kim, Seung-Hyeon Lee, Sang-Wang Lee, H. Sin, T. Lim, Seon-Young Kim, Mi Hee Park
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摘要

众所周知,黑莓(Rubus fruticosus)含有多种生物活性物质,其抗氧化特性已被广泛研究。黑莓具有多种有益健康的功效,包括抗炎、抗动脉粥样硬化、抗肿瘤和免疫调节活性。然而,发酵提取物的潜在生物效应和精确的分子机制在很大程度上仍未得到探索。在这项研究中,我们证明了用乳酸菌发酵的黑莓对解决肥胖问题的效果。我们研究了乳酸菌发酵的黑莓对以高脂肪(60% 千卡)饮食喂养 12 周的小鼠的影响。与肥胖组相比,服用发酵黑莓可减少高脂饮食引起的体重和附睾脂肪。作为血脂指标的甘油三酯和总胆固醇以及作为胰岛素抵抗指标的瘦素水平在肥胖组明显升高,但在发酵黑莓治疗组则明显降低。此外,CEBPα、PPAR-γ和SREBP-1等脂肪生成标志蛋白的表达在肥胖组明显增加,而在发酵黑莓处理组则有所减少。这些结果表明,发酵黑莓通过抑制脂肪生成对高脂饮食引起的肥胖具有保护作用,是治疗肥胖症的潜在候选药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-Obesity Properties of Blackberries Fermented with L. plantarum JBMI F5 via Suppression of Adipogenesis Signaling Mechanisms
Blackberries (Rubus fruticosus), which are known to include a variety of bioactive substances, have been extensively studied for their antioxidant properties. Blackberries possess multiple health beneficial effects, including anti-inflammation, anti-atherosclerosis, anti-tumor and immunomodulatory activity. However, the potential biological effects and precise molecular mechanisms of the fermented extracts remain largely unexplored. In this research, we demonstrate the effect of blackberries fermented with Lactobacillus for addressing obesity. We investigated the effect of blackberries fermented by Lactobacillus on mice fed a high-fat (60% kcal) diet for 12 weeks. Fermented blackberry administration reduced the body weight and epididymal fat caused by a high-fat diet compared to the obese group. The triglyceride and total cholesterol, which are blood lipid indicators, and the levels of leptin, which is an insulin resistance indicator, were significantly increased in the obese group but were significantly decreased in the fermented blackberries-treated group. Additionally, the expression of adipogenesis marker proteins, such as CEBPα, PPAR-γ and SREBP-1, was significantly increased in the obese group, whereas it was decreased in the fermented blackberries-treated group. These results suggest that fermented blackberries have a protective effect against high-fat-diet-induced obesity by inhibiting adipogenesis and are a potential candidate for the treatment of obesity.
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