探索 RNA 中 N4-乙酰胞嘧啶修饰对非肿瘤性疾病的影响:揭示其在发病机制中的作用和治疗机会。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Keyu Wan, Tiantian Nie, Wenhao Ouyang, Yunjing Xiong, Jing Bian, Ying Huang, Li Ling, Zhenjun Huang, Xianhua Zhu
{"title":"探索 RNA 中 N4-乙酰胞嘧啶修饰对非肿瘤性疾病的影响:揭示其在发病机制中的作用和治疗机会。","authors":"Keyu Wan, Tiantian Nie, Wenhao Ouyang, Yunjing Xiong, Jing Bian, Ying Huang, Li Ling, Zhenjun Huang, Xianhua Zhu","doi":"10.1093/bfgp/elae020","DOIUrl":null,"url":null,"abstract":"<p><p>RNA modifications include not only methylation modifications, such as m6A, but also acetylation modifications, which constitute a complex interaction involving \"writers,\" \"readers,\" and \"erasers\" that play crucial roles in growth, genetics, and disease. N4-acetylcytidine (ac4C) is an ancient and highly conserved RNA modification that plays a profound role in the pathogenesis of a wide range of diseases. This review provides insights into the functional impact of ac4C modifications in disease and introduces new perspectives for disease treatment. These studies provide important insights into the biological functions of post-transcriptional RNA modifications and their potential roles in disease mechanisms, offering new perspectives and strategies for disease treatment.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the impact of N4-acetylcytidine modification in RNA on non-neoplastic disease: unveiling its role in pathogenesis and therapeutic opportunities.\",\"authors\":\"Keyu Wan, Tiantian Nie, Wenhao Ouyang, Yunjing Xiong, Jing Bian, Ying Huang, Li Ling, Zhenjun Huang, Xianhua Zhu\",\"doi\":\"10.1093/bfgp/elae020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>RNA modifications include not only methylation modifications, such as m6A, but also acetylation modifications, which constitute a complex interaction involving \\\"writers,\\\" \\\"readers,\\\" and \\\"erasers\\\" that play crucial roles in growth, genetics, and disease. N4-acetylcytidine (ac4C) is an ancient and highly conserved RNA modification that plays a profound role in the pathogenesis of a wide range of diseases. This review provides insights into the functional impact of ac4C modifications in disease and introduces new perspectives for disease treatment. These studies provide important insights into the biological functions of post-transcriptional RNA modifications and their potential roles in disease mechanisms, offering new perspectives and strategies for disease treatment.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-06-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1093/bfgp/elae020\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1093/bfgp/elae020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0

摘要

RNA 修饰不仅包括甲基化修饰(如 m6A),还包括乙酰化修饰,它们构成了一种复杂的相互作用,涉及 "写者"、"读者 "和 "擦除者",在生长、遗传和疾病中发挥着至关重要的作用。N4-乙酰胞苷(ac4C)是一种古老而高度保守的 RNA 修饰,在多种疾病的发病机制中发挥着深远的作用。本综述深入探讨了 ac4C 修饰在疾病中的功能性影响,并为疾病治疗提供了新的视角。这些研究为了解转录后 RNA 修饰的生物学功能及其在疾病机制中的潜在作用提供了重要见解,为疾病治疗提供了新的视角和策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the impact of N4-acetylcytidine modification in RNA on non-neoplastic disease: unveiling its role in pathogenesis and therapeutic opportunities.

RNA modifications include not only methylation modifications, such as m6A, but also acetylation modifications, which constitute a complex interaction involving "writers," "readers," and "erasers" that play crucial roles in growth, genetics, and disease. N4-acetylcytidine (ac4C) is an ancient and highly conserved RNA modification that plays a profound role in the pathogenesis of a wide range of diseases. This review provides insights into the functional impact of ac4C modifications in disease and introduces new perspectives for disease treatment. These studies provide important insights into the biological functions of post-transcriptional RNA modifications and their potential roles in disease mechanisms, offering new perspectives and strategies for disease treatment.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信