单细胞多组学时代的糖医学和精准医学双奖学金。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2024-07-01 Epub Date: 2024-06-06 DOI:10.1089/omi.2024.0111
Seungyoul Oh, Weijie Cao, Manshu Song
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引用次数: 0

摘要

系统生物学和多组学研究拓展了地球健康创新的前景。在此背景下,这篇微型综述解读了当前单细胞多组学时代糖医学和精准医学的双重学术研究。过去十年来,糖研究取得了长足发展,揭示并确立了共翻译和翻译后修饰作为病理和生理状况动态指标的地位。系统生物学技术实现了大规模、高通量的糖谱分析,并为全球研究提供了数据密集型生物库。这些进步确立了聚糖与核酸和氨基酸一样,是生命的第三个关键密码。然而,挑战依然存在,特别是在同时分析单细胞中的糖粒和转录组方面,由于技术上的限制。此外,对糖组学和其他全微粒组学类型之间复杂的分子相互作用的整体看法仍然难以捉摸。我们强调并呼吁转变模式,探索用于单细胞多组学研究和精准医学生物标记物发现的综合性糖平台和分析方法。整合来自不同单细胞组学水平的多个数据集是系统生物学在理解复杂细胞过程中的重要应用,对于推进糖医学和精准医学这两项学术研究至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Twin Scholarships of Glycomedicine and Precision Medicine in Times of Single-Cell Multiomics.

Systems biology and multiomics research expand the prospects of planetary health innovations. In this context, this mini-review unpacks the twin scholarships of glycomedicine and precision medicine in the current era of single-cell multiomics. A significant growth in glycan research has been observed over the past decade, unveiling and establishing co- and post-translational modifications as dynamic indicators of both pathological and physiological conditions. Systems biology technologies have enabled large-scale and high-throughput glycoprofiling and access to data-intensive biological repositories for global research. These advancements have established glycans as a pivotal third code of life, alongside nucleic acids and amino acids. However, challenges persist, particularly in the simultaneous analysis of the glycome and transcriptome in single cells owing to technical limitations. In addition, holistic views of the complex molecular interactions between glycomics and other omics types remain elusive. We underscore and call for a paradigm shift toward the exploration of integrative glycan platforms and analysis methods for single-cell multiomics research and precision medicine biomarker discovery. The integration of multiple datasets from various single-cell omics levels represents a crucial application of systems biology in understanding complex cellular processes and is essential for advancing the twin scholarships of glycomedicine and precision medicine.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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