葡萄糖-6 磷酸脱氢酶综述:昆虫体内重要的免疫代谢和氧化还原开关

IF 7.7 1区 化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Muhammad Usman Ghani , Zihan Yang , Tianxiang Feng , Junfan Chen , Zahra Khosravi , Qishu Wu , Hongjuan Cui
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引用次数: 0

摘要

做出积极的免疫反应需要消耗大量能量,并需要重新分配营养物质,以维持机体对感染的抵抗力和耐受力。葡萄糖-6-磷酸脱氢酶(G6PDH)是这种新陈代谢适应的核心,它是磷酸戊糖途径(PPP)的管家酶。PPP 在生成核糖方面发挥着重要作用,而核糖对烟酰胺腺嘌呤二核苷酸磷酸(NADPH)至关重要。它对生理和细胞过程至关重要,如生成核苷酸、脂肪酸和减少氧化应激。G6PDH 是 PP 分流过程中物种间极为保守的酶。酶的缺乏会对生物体造成严重后果,尤其是对适应和发育。急性缺乏会导致细胞发育受损、胚胎生长停止、对胰岛素的敏感性降低、高血压和炎症加剧。一直以来,有关 G6PDH 和 PPP 的研究主要针对哺乳动物的疾病。然而,我们的综述研究了 G6PDH 酶在昆虫中的独特功能,大大提高了对其运作机理的认识。这篇综述探讨了昆虫体内的 G6PDH 如何在管理氧化还原平衡和免疫相关代谢中发挥关键作用。本研究旨在探讨该酶在不同代谢适应中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Comprehensive review on glucose 6 phosphate dehydrogenase: A critical immunometabolic and redox switch in insects

Comprehensive review on glucose 6 phosphate dehydrogenase: A critical immunometabolic and redox switch in insects

Mounting an active immune response is energy intensive and demands the reallocation of nutrients to maintain the body's resistance and tolerance against infections. Central to this metabolic adaptation is Glucose-6-phosphate dehydrogenase (G6PDH), a housekeeping enzyme involve in pentose phosphate pathway (PPP). PPP play an essential role in generating ribose, which is critical for nicotinamide adenine dinucleotide phosphate (NADPH). It is vital for physiological and cellular processes such as generating nucleotides, fatty acids and reducing oxidative stress. The G6PDH is extremely conserved enzyme across species in PP shunt. The deficiency of enzymes leads to serious consequences on organism, particularly on adaptation and development. Acute deficiency can lead to impaired cell development, halted embryonic growth, reduce sensitivity to insulin, hypertension and increase inflammation. Historically, research focusing on G6PDH and PPP have primarily targeted diseases on mammalian. However, our review has investigated the unique functions of the G6PDH enzyme in insects and greatly improved mechanistic understanding of its operations. This review explore how G6PDH in insects plays a crucial role in managing the redox balance and immune related metabolism. This study aims to investigate the enzyme's role in different metabolic adaptations.

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来源期刊
International Journal of Biological Macromolecules
International Journal of Biological Macromolecules 生物-生化与分子生物学
CiteScore
13.70
自引率
9.80%
发文量
2728
审稿时长
64 days
期刊介绍: The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.
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