Rho 家族小 GTP 酶在正常和病理过程调控中的作用

Q4 Biochemistry, Genetics and Molecular Biology

Cell and Tissue Biology Pub Date : 2024-06-03 DOI:10.1134/s1990519x24700159

D. E. Bobkov, A. V. Lukacheva, A. I. Gorb, G. G. Poljanskaya

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引用次数: 0

摘要

摘要小 GTP 酶是一种单体蛋白（约 21 kDa），可调节多种生物过程，如囊泡运输、细胞分裂周期、细胞迁移、侵袭、粘附、增殖和 DNA 修复。它们还与致癌和神经退行性疾病有关。其中一些蛋白，如 Rho 家族蛋白，是肌动蛋白细胞骨架的重要调节因子，控制着细胞的粘附和运动。本综述探讨了人体细胞中受 Rho 家族小 GTP 酶调控的正常和病理过程。其中特别关注小 GTP 酶抑制剂及其在治疗各种疾病中的应用。

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Role of Rho Family Small GTPases in the Regulation of Normal and Pathological Processes

Abstract

Small GTPases are monomeric (approximately 21 kDa) proteins that regulate a number of biological processes, such as vesicle transport, cell division cycle, cell migration, invasion, adhesion, proliferation, and DNA repair. They are also involved in carcinogenesis and neurodegenerative diseases. Some of these proteins, such as the Rho family proteins, are essential regulators of actin cytoskeleton, controlling cell adhesion and motility. This review examines both normal and pathological processes in human cells that are regulated by small GTPases of the Rho family. Particular attention is paid to small GTPase inhibitors and their use in the treatment of various diseases.

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来源期刊

Cell and Tissue Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The journal publishes papers on vast aspects of cell research, including morphology, biochemistry, biophysics, genetics, molecular biology, immunology. The journal accepts original experimental studies, theoretical articles suggesting novel principles and approaches, presentations of new hypotheses, reviews highlighting major developments in cell biology, discussions. The main objective of the journal is to provide a competent representation and integration of research made on cells (animal and plant cells, both in vivo and in cell culture) offering insight into the structure and functions of live cells as a whole. Characteristically, the journal publishes articles on biology of free-living and parasitic protists, which, unlike Metazoa, are eukaryotic organisms at the cellular level of organization.