新型 1-烷基-3-苯基和 3-烷基-1-苯基咪唑噻唑三嗪的合成及其抗肿瘤活性

IF 1.4 4区化学 Q3 CHEMISTRY, ORGANIC

Chemistry of Heterocyclic Compounds Pub Date : 2024-06-05 DOI:10.1007/s10593-024-03318-y

Alexei N. Izmest’ev, Sergey S. Isakov, Angelina N. Kravchenko, Galina A. Gazieva

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引用次数: 0

摘要

从 1-烷基-3-芳基-4,5-二羟基咪唑啉-2-(硫)-1 中获得了两组异构体咪唑并噻唑并[1,2,4]三嗪及其氧化吲哚亚基衍生物。合成的一种咪唑并[4,5-e]噻唑并[2,3-c][1,2,4]三嗪衍生物在 10 μmol/l 的浓度下对四种肿瘤细胞株具有很高的细胞抑制活性：HL-60（TB）（白血病，生长率-16.1%）、SF-539（中枢神经系统癌症，生长率-2.6%）、MDA-MB-435（黑色素瘤，生长率-21.2%）和 RXF 393（肾癌，生长率-6.1%）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The synthesis and antitumor activity of novel 1-alkyl-3-phenyland 3-alkyl-1-phenylimidazothiazolotriazines

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The synthesis and antitumor activity of novel 1-alkyl-3-phenyland 3-alkyl-1-phenylimidazothiazolotriazines

Two groups of isomeric imidazothiazolo[1,2,4]triazines and their oxindolylidene derivatives were obtained from 1-alkyl-3-aryl-4,5-dihydroxyimidazolidin-2-(thi)ones. One of the synthesized imidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazine derivatives showed high cytostatic activity at a concentration of 10 μmol/l against four lines of tumor cells: HL-60(TB) (leukemia, –16.1% growth rate), SF-539 (CNS cancer, –2.6% growth rate), MDA-MB-435 (melanoma, –21.2% growth rate), and RXF 393 (kidney cancer, –6.1 % growth rate).

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来源期刊

Chemistry of Heterocyclic Compounds 化学-有机化学

CiteScore

2.90

自引率

13.30%

发文量

审稿时长

1 months

期刊介绍： The international journal Chemistry of Heterocyclic Compounds publishes original papers, short communications, reviews, and mini-reviews dealing with problems in the field of heterocyclic chemistry in Russian and English. The Journal also publishes reviews and annotations on new books and brief reports on conferences in the field of heterocyclic chemistry, as well as commemoratives dedicated to prominent heterocyclic chemists.