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引用次数: 0
摘要
注射水凝胶是一种智能化的多功能材料,已被证明在药物输送、组织工程和再生医学等许多生物医学应用领域具有巨大潜力。水凝胶是一类具有高度水合三维网络的聚合物,具有与原生细胞外基质相似的微环境特性,如氧气/养分渗透性。除了具有传统水凝胶的典型优点外,可注射水凝胶还具有额外的独特功能,可进行微创注射,对形状不规则的部位具有耐久性,并可通过增材制造等技术加工这些材料。因此,人们对使用可注射水凝胶作为治疗剂(包括但不限于药物、细胞、蛋白质和生物活性分子)的支架/载体越来越感兴趣,这些治疗剂不仅可用于治疗包括癌症在内的慢性疾病,还可促进受损器官/组织的修复和再生。在这本《材料化学 B 与生物材料科学杂志》的主题文集中,我们收录了一些杰出的论文,内容涵盖了可注射水凝胶这一快速发展领域的最新进展,包括可注射水凝胶的新兴化学成分、合成途径、制造方法、细胞与材料的相互作用、体外、体内和体外性能以及后续的针对性应用(药物输送、组织工程和再生医学)。
Injectable hydrogels have emerged as intelligent and versatile materials that have been proven to possess huge potential for many biomedical applications including drug delivery, tissue engineering, and regenerative medicine. Hydrogels are a class of polymers with highly hydrated 3D networks that have microenvironmental properties such as oxygen/nutrient permeability that are similar to the native extracellular matrix. In addition to possessing the typical advantages of conventional hydrogels, injectable hydrogels offer extra unique features, enabling minimally invasive injectability and durability for irregularly shaped sites, and the possibility of processing these materials via, e.g., additive manufacturing techniques. As such, there has been a growing interest in using injectable hydrogels as scaffolds/carriers for therapeutic agents, including but not limited to drugs, cells, proteins, and bioactive molecules, targeted to treat chronic diseases including cancer, but also to facilitate the repair and regeneration of damaged organs/tissues. In this themed collection of Journal of Materials Chemistry B and Biomaterials Science, we include outstanding contributions covering recent developments in this rapidly evolving field of injectable hydrogels including emerging chemistries, synthesis pathways, fabrication methods, cell–material interaction, in vitro, ex vivo and in vivo performances, and subsequent targeted applications (drug delivery, tissue engineering and regenerative medicine) of injectable hydrogels.
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices