A Guariglia, C Antonucci, E Coffrini, S Del Canale, E Fiaccadori, F Reni, P Vitali, U Arduini, A Borghetti
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Intracellular bicarbonate and pH of skeletal muscle in chronic renal failure.
In 11 controls and 10 patients suffering from untreated uraemic acidosis intracellular bicarbonate and skeletal muscle pH (needle biopsy) were determined. In all patients a significant intracellular acidosis, not related to any extracellular indices was found. It is concluded that the chronic proton load is able to effect intracellular buffer composition; moreover the action of other factors such as derangements of cell metabolism and nutritional imbalance could be operating.
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