通过遗传学推动儿科 VTE 风险分级的精确性。

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science Pub Date : 2024-05-31 eCollection Date: 2024-01-01

Samaya S Badrieh, Lisa Bastarache, Xinnan Niu, Jing He, Jamie R Robinson

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摘要

本研究利用英国生物库数据验证了 VTE 表型并制定了多基因风险评分 (PRS)，从而解决了儿科静脉血栓栓塞发病率上升的问题。我们的研究结果证明了多基因风险评分的预测价值，从而加强了临床环境中的 VTE 风险评估。未来的工作包括将多基因风险评分纳入风险分层模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Driving Precision of Pediatric VTE Risk-stratification through Genetics.

This study addresses rising incidence of pediatric venous thromboembolism by validating a VTE phenotype and developing a polygenic risk score (PRS) using UK Biobank data. Our findings demonstrate predictive value of the PRS, enhancing VTE risk assessment in clinical settings. Future steps involve integrating the PRS into risk stratification models.

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AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

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