当雷击两次：年轻患者罹患第二种恶性肿瘤的途径。

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2024-06-03 DOI:10.1158/2159-8290.CD-24-0325

Clarissa N Pacyna, Jyoti Nangalia

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引用次数: 0

摘要

摘要：鉴于儿童癌症的罕见性，儿科癌症幸存者罹患第二种独立恶性肿瘤的情况应该更加罕见，但他们在初次缓解后罹患第二种恶性肿瘤的风险却大大增加。在本期《癌症发现》（Cancer Discovery）杂志上，桑切斯-吉塞（Sánchez-Guixé）及其同事揭示了四名儿童二次肿瘤的起源，以及铂类化疗在随后的肿瘤发生中可能扮演的角色。请参阅 Sánchez-Guixé 等人的相关文章，第 953 页（8）。

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When Lightning Strikes Twice: Routes to Second Malignancies in Young Patients.

Summary: Given the rarity of cancer in childhood, it should be even more uncommon for pediatric cancer survivors to develop a second, independent malignancy, yet they incur a greatly elevated risk after initial remission. In this issue of Cancer Discovery, Sánchez-Guixé and colleagues unpick the origins of second tumours in four children, and the potential role platinum-based chemotherapy may play in subsequent tumorigenesis. See related article by Sánchez-Guixé et al., p. 953 (8).

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.