GWAS 揭示了非洲裔儿童对空气污染导致的哮喘恶化的遗传易感性

medRxiv - Pediatrics Pub Date : 2024-05-29 DOI:10.1101/2024.05.29.24307906

Jelte Kelchtermans, Michael E. March, Frank Mentch, Yichuan Liu, Kenny Nguyen, Hakon Hakonarson

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引用次数: 0

摘要

背景环境空气污染（AAP）暴露与哮喘恶化之间的关系已得到证实。然而，由于对 AAP 的反应存在遗传变异，缓解工作的结果不尽相同。我们假设常见的单核苷酸多态性（SNPs）与哮喘敏感性有关，并通过一项全基因组关联研究（GWAS）对此进行了检验。

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GWAS reveals Genetic Susceptibility to Air Pollution-Related Asthma Exacerbations in Children of African Ancestry

Background The relationship between ambient air pollution (AAP) exposure and asthma exacerbations is well-established. However, mitigation efforts have yielded mixed results, potentially due to genetic variability in the response to AAP. We hypothesize that common single nucleotide polymorphisms (SNPs) are linked to AAP sensitivity and test this through a Genome Wide Association Study (GWAS).

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medRxiv - Pediatrics

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