血管化复合体同种异体移植中组织工程的新策略:综述

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING
Danyang Ren, Jun Chen, Meirong Yu, Chenggang Yi, Xueqing Hu, Junjie Deng, Songxue Guo
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引用次数: 0

摘要

血管化复合异体移植(VCA)可有效改善生活质量,是面部或身体创伤后修复和重建的一种前景广阔的疗法。然而,血管化复合体同种异体移植存在一些难以解决的问题,如不同组织不可避免的多重免疫原性会导致严重的排斥反应、临床应用的方案有限以及供体来源短缺等。为了延长接受 VCA 患者的生存期并抑制排斥反应,现有的治疗方案通常是终身应用免疫抑制剂,但这些药物都有副作用。因此,针对 VCA 的组织工程学方法研究已成为一个主题。在这篇综述中,我们总结了新出现的旨在延长 VCA 移植物存活时间、延缓排斥反应、促进血管前化和组织再生的组织工程治疗策略,为今后的 VCA 治疗研究提供新思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emerging strategies for tissue engineering in vascularized composite allotransplantation: A review
Vascularized composite allotransplantation (VCA), which can effectively improve quality of life, is a promising therapy for repair and reconstruction after face or body trauma. However, intractable issues are associated with VCA, such as the inevitable multiple immunogenicities of different tissues that cause severe rejection, the limited protocols available for clinical application, and the shortage of donor sources. The existing regimens used to extend the survival of patients receiving VCAs and suppress rejection are generally the lifelong application of immunosuppressive drugs, which have side effects. Consequently, studies aiming at tissue engineering methods for VCA have become a topic. In this review, we summarize the emerging therapeutic strategies for tissue engineering aimed to prolong the survival time of VCA grafts, delay the rejection and promote prevascularization and tissue regeneration to provide new ideas for future research on VCA treatment.
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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
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