2007-2019 年埃及达米埃塔病毒性和非病毒性肝细胞癌的发病、治疗和存活率比较

IF 4.2 3区 医学 Q2 ONCOLOGY
Kévin Jean, Ahmed Tawheed, Liem Binh Luong Nguyen, Tarek Heikal, Usama Eldaly, Neveen Gaber Elhadidy, Ahmed Elghaieb, Ahmed Aboudonia, Laura Tondeur, Amélie Dublineau, Arnaud Fontanet, Mohamed El-Kassas
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引用次数: 0

摘要

背景:在埃及,被诊断为病毒性与非病毒性肝细胞癌(HCC)患者的预后差异仍不明确:我们使用了达米埃塔肿瘤学转诊中心(埃及北部)大型单中心回顾性队列中 2007 年至 2019 年期间确诊的 HCC 患者的数据。比较了病毒性和非病毒性病因 HCC 患者的发病和治疗情况。通过单变量和多变量 Cox 回归对生存率进行了比较:结果:分析了 4714 名 HCC 患者的数据。结果:分析了 4714 名 HCC 患者的数据,其中 204 人(4.3%)的病因与病毒无关。非病毒性病因与病毒性病因患者的总体表现相似,尤其是在确诊HCC时的BCLC分期方面。在控制了各种个体特征后,非病毒性病因与病毒性病因患者的生存率较低(调整后危险比:1.244;95% 置信区间:1.069- 1.447):关键词:肝细胞癌;肝癌;病毒病因;非病毒病因;生存;流行病学
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Comparison of Presentation, Treatment, and Survival After Hepatocellular Carcinoma of Viral and Non-Viral Etiology in Damietta, Egypt, 2007–2019
Context: The difference in prognosis between patients diagnosed with viral versus non-viral hepatocellular carcinoma (HCC) in Egypt remains unclear.
Methods: We used data from patients diagnosed with HCC between 2007 and 2019 from a large monocentric retrospective cohort at the Damietta Oncology referral center (northern Egypt). Presentation and treatment were compared between viral versus non-viral etiology HCC patients. Survival was compared relying on univariate and multivariate Cox regressions.
Results: Data from 4714 HCC patients were analyzed. Among them, 204 (4.3%) presented with a non-viral etiology. Patients with non-viral versus viral etiology had a similar presentation overall, especially regarding the BCLC stage at HCC diagnosis. After controlling for various individual characteristics, patients with non-viral versus viral etiology had poorer survival (adjusted Hazard Ratio: 1.244; 95% Confidence Interval: 1.069– 1.447).
Conclusion: Despite similar features, patients with non-viral- related HCC had poorer survival compared to patients with viral-related HCC.

Keywords: hepatocellular carcinoma, liver cancer, viral etiology, non-viral etiology, survival, epidemiology
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来源期刊
CiteScore
0.50
自引率
2.40%
发文量
108
审稿时长
16 weeks
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