2007-2019 年埃及达米埃塔病毒性和非病毒性肝细胞癌的发病、治疗和存活率比较

IF 4.2 3区医学 Q2 ONCOLOGY

Journal of Hepatocellular Carcinoma Pub Date : 2024-05-31 DOI:10.2147/jhc.s455832

Kévin Jean, Ahmed Tawheed, Liem Binh Luong Nguyen, Tarek Heikal, Usama Eldaly, Neveen Gaber Elhadidy, Ahmed Elghaieb, Ahmed Aboudonia, Laura Tondeur, Amélie Dublineau, Arnaud Fontanet, Mohamed El-Kassas

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引用次数: 0

摘要

背景：在埃及，被诊断为病毒性与非病毒性肝细胞癌（HCC）患者的预后差异仍不明确：我们使用了达米埃塔肿瘤学转诊中心（埃及北部）大型单中心回顾性队列中 2007 年至 2019 年期间确诊的 HCC 患者的数据。比较了病毒性和非病毒性病因 HCC 患者的发病和治疗情况。通过单变量和多变量 Cox 回归对生存率进行了比较：结果：分析了 4714 名 HCC 患者的数据。结果：分析了 4714 名 HCC 患者的数据，其中 204 人（4.3%）的病因与病毒无关。非病毒性病因与病毒性病因患者的总体表现相似，尤其是在确诊HCC时的BCLC分期方面。在控制了各种个体特征后，非病毒性病因与病毒性病因患者的生存率较低（调整后危险比：1.244；95% 置信区间：1.069- 1.447）：关键词：肝细胞癌；肝癌；病毒病因；非病毒病因；生存；流行病学

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A Comparison of Presentation, Treatment, and Survival After Hepatocellular Carcinoma of Viral and Non-Viral Etiology in Damietta, Egypt, 2007–2019

Context: The difference in prognosis between patients diagnosed with viral versus non-viral hepatocellular carcinoma (HCC) in Egypt remains unclear.
Methods: We used data from patients diagnosed with HCC between 2007 and 2019 from a large monocentric retrospective cohort at the Damietta Oncology referral center (northern Egypt). Presentation and treatment were compared between viral versus non-viral etiology HCC patients. Survival was compared relying on univariate and multivariate Cox regressions.
Results: Data from 4714 HCC patients were analyzed. Among them, 204 (4.3%) presented with a non-viral etiology. Patients with non-viral versus viral etiology had a similar presentation overall, especially regarding the BCLC stage at HCC diagnosis. After controlling for various individual characteristics, patients with non-viral versus viral etiology had poorer survival (adjusted Hazard Ratio: 1.244; 95% Confidence Interval: 1.069– 1.447).
Conclusion: Despite similar features, patients with non-viral- related HCC had poorer survival compared to patients with viral-related HCC.

Keywords: hepatocellular carcinoma, liver cancer, viral etiology, non-viral etiology, survival, epidemiology

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来源期刊

Journal of Hepatocellular Carcinoma ONCOLOGY-

CiteScore

0.50

自引率

2.40%

发文量

108

审稿时长

16 weeks