香蜂草提取物对人胃癌细胞的抗肿瘤活性和酚类物质概况

IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Alaa A Hashim, Dhiya Altememy, Mohammed H Mahdi, Sima Salmani, Sepideh Parvizpour, Akram Alizadeh, Sorayya Ghasemi
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引用次数: 0

摘要

胃癌仍然是全球关注的健康问题,这推动了对具有抗癌潜力的天然产品的探索。本研究调查了 Melissa officinalis L. 的 70% 乙醇提取物对人类胃癌细胞的抗增殖活性和化学成分。研究人员制备了这种提取物,并对其总酚含量、抗氧化能力和类黄酮含量进行了评估。MTT 试验检测了其阻止人胃腺癌(AGS)和正常真皮成纤维细胞(HDF)生长的效果。数据分析(SPSS 统计)确定了存活细胞的百分比,并对 24、48 和 72 小时的 p50 值(564.3、258.0 和 122.5 μg/ml)进行了回归分析。它还显示出抗氧化活性(IC50=16.8±1.41μg/ml),并含有大量酚类化合物(225.76±4.1 mg GAE/g)和黄酮类化合物(22.36±2.6 mg RUT/g)。这项研究表明,70%的M. officinalis乙醇提取物能有效抑制AGS细胞的生长,并具有良好的抗氧化性,突出了其作为抗癌和抗氧化剂天然来源的潜力,值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antitumor activity and phenolic profile of Melissa officinalis extract against human gastric adenocarcinoma cells.

Gastric cancer remains a global health concern, driving the exploration of natural products with anticancer potential. This study investigated the antiproliferative activity and chemical composition of a 70% ethanolic extract from Melissa officinalis L. against human gastric cancer cells. The extract was prepared and evaluated for total phenolic content, antioxidant capacity and flavonoid content. The MTT test checked how well it stopped the growth of human gastric adenocarcinoma (AGS) and normal dermal fibroblast (HDF) cells. Data analysis (SPSS Statistics) determined viable cell percentages and performed regression analysis (p<0.05). The extract exhibited significant antiproliferative activity against AGS cells compared to normal cells (p<0.05), with decreasing IC50 values (564.3, 258.0 and 122.5 μg/ml) over 24, 48 and 72 hours. It also displayed antioxidant activity (IC50=16.8±1.41μg/ml) and contained substantial phenolics (225.76±4.1 mg GAE/g) and flavonoids (22.36±2.6 mg RUT/g). This study suggests the 70% ethanolic extract of M. officinalis effectively suppresses AGS cell growth and possesses promising antioxidant properties, highlighting its potential as a natural source of anticancer and antioxidant agents, deserving further investigation.

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来源期刊
CiteScore
1.40
自引率
12.50%
发文量
211
审稿时长
4.5 months
期刊介绍: Pakistan Journal of Pharmaceutical Sciences (PJPS) is a peer reviewed multi-disciplinary pharmaceutical sciences journal. The PJPS had its origin in 1988 from the Faculty of Pharmacy, University of Karachi as a biannual journal, frequency converted as quarterly in 2005, and now PJPS is being published as bi-monthly from January 2013. PJPS covers Biological, Pharmaceutical and Medicinal Research (Drug Delivery, Pharmacy Management, Molecular Biology, Biochemical, Pharmacology, Pharmacokinetics, Phytochemical, Bio-analytical, Therapeutics, Biotechnology and research on nano particles.
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