心肌桥和动脉粥样硬化,一种内在关系。

IF 5.7 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Current Atherosclerosis Reports Pub Date : 2024-08-01 Epub Date: 2024-06-01 DOI:10.1007/s11883-024-01219-1
Benjamin De Ornelas, Vincenzo Sucato, Giuseppe Vadalà, Andrea Buono, Alfredo Ruggero Galassi
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引用次数: 0

摘要

综述的目的:这篇综述探讨了心肌桥(MBs)、冠状动脉内膜增厚和动脉粥样硬化性心血管疾病之间的关系。研究重点是机械力(如周向应变)在动脉壁重塑中的作用,旨在阐明 MB 如何影响冠状动脉病理学:已确定 MB 在调节冠状动脉内膜厚度方面具有影响力,它对 MB 区段内的增厚具有保护作用,并增加 MB 近端的厚度。这归因于机械应力和血液动力学的变化。涉及动脉高血压模型和静脉移植疾病的研究强调了周向应变在血管重塑和内膜增生中的重要性。了解 MB、机械应变和血管重塑之间复杂的动态变化,对于增进我们对冠状动脉疾病机制的了解至关重要。这将有助于改善心血管疾病的管理策略,突出了进一步研究 MB 相关血管变化的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Myocardial Bridge and Atherosclerosis, an Intimal Relationship.

Myocardial Bridge and Atherosclerosis, an Intimal Relationship.

Purpose of review: This review investigates the relationship between myocardial bridges (MBs), intimal thickening in coronary arteries, and Atherosclerotic cardiovascular disease. It focuses on the role of mechanical forces, such as circumferential strain, in arterial wall remodeling and aims to clarify how MBs affect coronary artery pathology.

Review findings: MBs have been identified as influential in modulating coronary artery intimal thickness, demonstrating a protective effect against thickening within the MB segment and an increase in thickness proximal to the MB. This is attributed to changes in mechanical stress and hemodynamics. Research involving arterial hypertension models and vein graft disease has underscored the importance of circumferential strain in vascular remodeling and intimal hyperplasia. Understanding the complex dynamics between MBs, mechanical strain, and vascular remodeling is crucial for advancing our knowledge of coronary artery disease mechanisms. This could lead to improved management strategies for cardiovascular diseases, highlighting the need for further research into MB-related vascular changes.

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来源期刊
CiteScore
9.00
自引率
3.40%
发文量
87
审稿时长
6-12 weeks
期刊介绍: The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.
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