{"title":"哌醋甲酯对注意力缺陷多动障碍儿童运动时多巴胺和生长激素反应的影响。","authors":"Dan Nemet , Sigal Ben-Zaken , Alon Eliakim","doi":"10.1016/j.ghir.2024.101596","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>To assess the growth hormone (GH) and Dopamine (DA) response to exercise in children with attention-deficit hyperactivity disorder (ADHD) with and without methylphenidate (MP). We hypothesized that the GH and DA response to the exercise with MP would be siginicantly lower.</p></div><div><h3>Methods</h3><p>Twenty children participated in the study (12 males and 8 females, age range 9–13 years). Ten with ADHD and 10 controls. Participants with ADHD performed an exercise test <em>twice</em>, with and without MP while controls performed one exercise test. Blood samples for GH and DA were collected before, at peak, 30 and 60 min after the end of exercise.</p></div><div><h3>Results</h3><p>Compared to controls, children with ADHD with and without MP, had a significantly lower GH (<em>P</em> < .002) and DA (<em>P</em> < .01) responses to exercise. In participants with ADHD, a significantly greater GH response (<em>p</em> < .04) to exercise was found when MP administered to the children before exercise, yet this response was still significantly lower than controls.</p></div><div><h3>Conclusions</h3><p>GH and DA excretion after an exercise challenge in children with ADHD is impaired. MP slightly attenuates the GH blunted response. This may link ADHD with growth impairment in some children and explain previous findings indicating that the final adult height is usually not compromised in children with ADHD treated with MP. The combined exercise and stimulant treatment therapeutic effects needs to be further explored.</p><p>Trial registration number: <span>NCT00945971</span><svg><path></path></svg></p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"76 ","pages":"Article 101596"},"PeriodicalIF":1.6000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of methylphenidate on the dopamine and growth hormone response to exercise in children with attention-deficit hyperactivity disorder\",\"authors\":\"Dan Nemet , Sigal Ben-Zaken , Alon Eliakim\",\"doi\":\"10.1016/j.ghir.2024.101596\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>To assess the growth hormone (GH) and Dopamine (DA) response to exercise in children with attention-deficit hyperactivity disorder (ADHD) with and without methylphenidate (MP). We hypothesized that the GH and DA response to the exercise with MP would be siginicantly lower.</p></div><div><h3>Methods</h3><p>Twenty children participated in the study (12 males and 8 females, age range 9–13 years). Ten with ADHD and 10 controls. Participants with ADHD performed an exercise test <em>twice</em>, with and without MP while controls performed one exercise test. Blood samples for GH and DA were collected before, at peak, 30 and 60 min after the end of exercise.</p></div><div><h3>Results</h3><p>Compared to controls, children with ADHD with and without MP, had a significantly lower GH (<em>P</em> < .002) and DA (<em>P</em> < .01) responses to exercise. In participants with ADHD, a significantly greater GH response (<em>p</em> < .04) to exercise was found when MP administered to the children before exercise, yet this response was still significantly lower than controls.</p></div><div><h3>Conclusions</h3><p>GH and DA excretion after an exercise challenge in children with ADHD is impaired. MP slightly attenuates the GH blunted response. This may link ADHD with growth impairment in some children and explain previous findings indicating that the final adult height is usually not compromised in children with ADHD treated with MP. The combined exercise and stimulant treatment therapeutic effects needs to be further explored.</p><p>Trial registration number: <span>NCT00945971</span><svg><path></path></svg></p></div>\",\"PeriodicalId\":12803,\"journal\":{\"name\":\"Growth Hormone & Igf Research\",\"volume\":\"76 \",\"pages\":\"Article 101596\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Growth Hormone & Igf Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1096637424000261\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Growth Hormone & Igf Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1096637424000261","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
The effect of methylphenidate on the dopamine and growth hormone response to exercise in children with attention-deficit hyperactivity disorder
Purpose
To assess the growth hormone (GH) and Dopamine (DA) response to exercise in children with attention-deficit hyperactivity disorder (ADHD) with and without methylphenidate (MP). We hypothesized that the GH and DA response to the exercise with MP would be siginicantly lower.
Methods
Twenty children participated in the study (12 males and 8 females, age range 9–13 years). Ten with ADHD and 10 controls. Participants with ADHD performed an exercise test twice, with and without MP while controls performed one exercise test. Blood samples for GH and DA were collected before, at peak, 30 and 60 min after the end of exercise.
Results
Compared to controls, children with ADHD with and without MP, had a significantly lower GH (P < .002) and DA (P < .01) responses to exercise. In participants with ADHD, a significantly greater GH response (p < .04) to exercise was found when MP administered to the children before exercise, yet this response was still significantly lower than controls.
Conclusions
GH and DA excretion after an exercise challenge in children with ADHD is impaired. MP slightly attenuates the GH blunted response. This may link ADHD with growth impairment in some children and explain previous findings indicating that the final adult height is usually not compromised in children with ADHD treated with MP. The combined exercise and stimulant treatment therapeutic effects needs to be further explored.
期刊介绍：
Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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