NAT10 和 mRNA 中的胞苷乙酰化：发育和疾病的交叉路径。

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2024-05-30 DOI:10.1016/j.gde.2024.102207

Cyrinne Achour, Shalini Oberdoerffer

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引用次数: 0

摘要

N4-acetylcytidine (ac4C) 是一种由 NAT10 酶催化的 RNA 修饰。ac4C可在tRNA和rRNA中持续存在，它在mRNA中的存在是动态的，受NAT10水平的发育和诱导变化的影响。然而，由于 ac4C 在翻译中的影响取决于上下文，而且从其他 NAT10 活性中分离出对特定 mRNA 的影响非常复杂，因此一直阻碍着对 ac4C 在 mRNA 中功能的解读。通过利用癌症、发育转变和免疫反应中 mRNA 乙酰化的自然变化，最近的研究进展已开始克服这些障碍。在此，我们对当前的文献进行了综述，重点关注可能会加剧细胞差异感知的细微差别，从而建立一个关于 ac4C 在 mRNA 中功能的连贯模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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NAT10 and cytidine acetylation in mRNA: intersecting paths in development and disease

N4-acetylcytidine (ac4C) is an RNA modification that is catalyzed by the enzyme NAT10. Constitutively found in tRNA and rRNA, ac4C displays a dynamic presence in mRNA that is shaped by developmental and induced shifts in NAT10 levels. However, deciphering ac4C functions in mRNA has been hampered by its context-dependent influences in translation and the complexity of isolating effects on specific mRNAs from other NAT10 activities. Recent advances have begun to overcome these obstacles by leveraging natural variations in mRNA acetylation in cancer, developmental transitions, and immune responses. Here, we synthesize the current literature with a focus on nuances that may fuel the perception of cellular discrepancies toward the development of a cohesive model of ac4C function in mRNA.

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)