{"title":"微针:用于眼科治疗的微创传输系统","authors":"Jayesh Jathar, Hitendra Mahajan, Pankaj Nerkar","doi":"10.1016/j.pharma.2024.05.007","DOIUrl":null,"url":null,"abstract":"<p><p>This review article delves into the extensive use of microneedles in ocular therapy, emphasizing their efficacy in delivering drug substances to the posterior region of the eye. The conventional methods of drug delivery, while widely employed, are marred by inherent drawbacks such as neovascularization, abrasion, and infiltration. To address these limitations, the review explores various approaches to microneedle fabrication, shedding light on the diverse materials employed in the process. Furthermore, the article meticulously examines the delivered drug substances using distinct microneedle approaches and their applications in ocular therapy. By critically evaluating the drawbacks associated with conventional ophthalmic drug delivery, the review seeks to pave the way for a paradigm shift. It advocates for a novel approach centered around minimally invasive microneedles, presenting them as a promising solution to overcome the limitations of current drug delivery methods. The comprehensive discussion within this article not only offers insights into the fabrication techniques and materials used for microneedles but also provides a nuanced understanding of the applications and advantages associated with this innovative approach. As the exploration of microneedle technology continues to evolve, this review serves as a valuable resource for researchers, clinicians, and pharmaceutical professionals seeking to enhance ocular therapy by embracing the potential of minimally invasive microneedles.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microneedles: A minimally invasive delivery system for ocular treatment.\",\"authors\":\"Jayesh Jathar, Hitendra Mahajan, Pankaj Nerkar\",\"doi\":\"10.1016/j.pharma.2024.05.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This review article delves into the extensive use of microneedles in ocular therapy, emphasizing their efficacy in delivering drug substances to the posterior region of the eye. The conventional methods of drug delivery, while widely employed, are marred by inherent drawbacks such as neovascularization, abrasion, and infiltration. To address these limitations, the review explores various approaches to microneedle fabrication, shedding light on the diverse materials employed in the process. Furthermore, the article meticulously examines the delivered drug substances using distinct microneedle approaches and their applications in ocular therapy. By critically evaluating the drawbacks associated with conventional ophthalmic drug delivery, the review seeks to pave the way for a paradigm shift. It advocates for a novel approach centered around minimally invasive microneedles, presenting them as a promising solution to overcome the limitations of current drug delivery methods. The comprehensive discussion within this article not only offers insights into the fabrication techniques and materials used for microneedles but also provides a nuanced understanding of the applications and advantages associated with this innovative approach. As the exploration of microneedle technology continues to evolve, this review serves as a valuable resource for researchers, clinicians, and pharmaceutical professionals seeking to enhance ocular therapy by embracing the potential of minimally invasive microneedles.</p>\",\"PeriodicalId\":8332,\"journal\":{\"name\":\"Annales pharmaceutiques francaises\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-05-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annales pharmaceutiques francaises\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.pharma.2024.05.007\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales pharmaceutiques francaises","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.pharma.2024.05.007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Microneedles: A minimally invasive delivery system for ocular treatment.
This review article delves into the extensive use of microneedles in ocular therapy, emphasizing their efficacy in delivering drug substances to the posterior region of the eye. The conventional methods of drug delivery, while widely employed, are marred by inherent drawbacks such as neovascularization, abrasion, and infiltration. To address these limitations, the review explores various approaches to microneedle fabrication, shedding light on the diverse materials employed in the process. Furthermore, the article meticulously examines the delivered drug substances using distinct microneedle approaches and their applications in ocular therapy. By critically evaluating the drawbacks associated with conventional ophthalmic drug delivery, the review seeks to pave the way for a paradigm shift. It advocates for a novel approach centered around minimally invasive microneedles, presenting them as a promising solution to overcome the limitations of current drug delivery methods. The comprehensive discussion within this article not only offers insights into the fabrication techniques and materials used for microneedles but also provides a nuanced understanding of the applications and advantages associated with this innovative approach. As the exploration of microneedle technology continues to evolve, this review serves as a valuable resource for researchers, clinicians, and pharmaceutical professionals seeking to enhance ocular therapy by embracing the potential of minimally invasive microneedles.
期刊介绍:
This journal proposes a scientific information validated and indexed to be informed about the last research works in all the domains interesting the pharmacy. The original works, general reviews, the focusing, the brief notes, subjected by the best academics and the professionals, propose a synthetic approach of the last progress accomplished in the concerned sectors. The thematic Sessions and the – life of the Academy – resume the communications which, presented in front of the national Academy of pharmacy, are in the heart of the current events.