中国深圳意义未定的单克隆丙种球蛋白病发病率。

IF 2 4区医学 Q3 HEMATOLOGY

Hematology Pub Date : 2024-12-01 Epub Date: 2024-05-31 DOI:10.1080/16078454.2024.2352686

Anping Xu, Tong Guo, Shuping Zhang, Houlong Luo, Mengxue Shen, Yinghui Ye, Ling Ji

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引用次数: 0

摘要

背景：有关中国意义未定单克隆丙种球蛋白病（MGUS）患病率的数据非常有限。我们的目的是确定 MGUS 在大量中国人群中的患病率和临床特征：本研究纳入了 49,220 名接受血清免疫固定电泳（sIFE）和血清蛋白电泳（SPE）检测的健康人群。对所有 M 蛋白患者进行了血清游离轻链比值、免疫球蛋白定量以及 MGUS 的其他临床相关指标检测：sIFE共发现576名MGUS患者，中位年龄为58岁，总患病率为1.17%（95% CI，1.08-1.27）。在 50 岁及以上人群中，MGUS 患病率为 2.26%（95% CI，2.04-2.50）。男性的 MGUS 患病率明显高于女性（P 结论：男性的 MGUS 患病率明显低于女性：华南地区的 MGUS 患病率远低于白人和黑人。

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Prevalence of monoclonal gammopathy of undetermined significance in Shenzhen, China.

Background: Data on the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in China are very limited. Our aim was to determine the prevalence and clinical characteristics of MGUS in a large Chinese population.

Methods: This study included 49,220 healthy people who received serum immunofixation electrophoresis (sIFE) and serum protein electrophoresis (SPE) tests. Serum free light chain ratio, immunoglobulin quantification, and other clinically correlates of MGUS were performed for all patients with M-protein.

Results: A total of 576 MGUS patients were identified by sIFE, with a median age of 58 years and an overall prevalence of 1.17% (95% CI, 1.08-1.27). Among those aged 50 years and older, the prevalence of MGUS was 2.26% (95% CI, 2.04-2.50). The prevalence of MGUS was significantly higher in males than in females (P < 0.05). The median concentration of M-protein was 3.1 g/L, ranging from 0.5 g/L to 25.1 g/L. The M-protein type was IgG in 55.4% of MGUS patients, followed by IgA (31.1%), IgM (9.5%), IgD (0.5%), biclonal (2.3%), and light chain (1.2%). Abnormalities in SPE, FLC ratios, and immunoglobulin levels were observed in 78.3%, 31.1%, and 38.4% of MGUS patients, respectively.

Conclusions: The prevalence of MGUS is substantially lower in southern China than in whites and blacks.

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来源期刊

Hematology 医学-血液学

CiteScore

2.60

自引率

5.30%

发文量

140

审稿时长

3 months

期刊介绍： Hematology is an international journal publishing original and review articles in the field of general hematology, including oncology, pathology, biology, clinical research and epidemiology. Of the fixed sections, annotations are accepted on any general or scientific field: technical annotations covering current laboratory practice in general hematology, blood transfusion and clinical trials, and current clinical practice reviews the consensus driven areas of care and management.