依赖磷酸吡哆醛的酶的新反应

IF 6.9 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Chemical Biology Pub Date : 2024-05-29 DOI:10.1016/j.cbpa.2024.102472

Phillip Daniel-Ivad, Katherine S. Ryan

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引用次数: 0

摘要

磷酸吡哆醛（PLP）是酶学中广泛使用的一种辅助因子。这种含吡啶的辅助因子可用于从转氨到氧化的各种反应。考虑到这种辅助因子的化学特征，就可以理解其催化的多功能性。近年来，在天然产物的生物合成中发现了涉及 PLP 的令人兴奋的新反应，颠覆了我们对这种辅助因子能力的认识。在此，我们将回顾过去五年中一些最激动人心的 PLP 依赖性反应。

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New reactions by pyridoxal phosphate-dependent enzymes

Pyridoxal phosphate (PLP) is a cofactor that is widely employed in enzymology. This pyridine-containing cofactor can be used for reactions ranging from transaminations to oxidations. The catalytic versatility can be understood by considering the chemical features of this cofactor. In recent years, exciting new reactions involving PLP have been discovered in natural products biosynthesis, upending our understanding of what this cofactor is capable of. Here we review some of the most exciting PLP-dependent reactions from the last five years.

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来源期刊

Current Opinion in Chemical Biology 生物-生化与分子生物学

CiteScore

13.30

自引率

1.30%

发文量

113

审稿时长

74 days

期刊介绍： COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.