依赖磷酸吡哆醛的酶的新反应

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-05-29 DOI:10.1016/j.cbpa.2024.102472

Phillip Daniel-Ivad, Katherine S. Ryan

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引用次数: 0

摘要

磷酸吡哆醛（PLP）是酶学中广泛使用的一种辅助因子。这种含吡啶的辅助因子可用于从转氨到氧化的各种反应。考虑到这种辅助因子的化学特征，就可以理解其催化的多功能性。近年来，在天然产物的生物合成中发现了涉及 PLP 的令人兴奋的新反应，颠覆了我们对这种辅助因子能力的认识。在此，我们将回顾过去五年中一些最激动人心的 PLP 依赖性反应。

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New reactions by pyridoxal phosphate-dependent enzymes

Pyridoxal phosphate (PLP) is a cofactor that is widely employed in enzymology. This pyridine-containing cofactor can be used for reactions ranging from transaminations to oxidations. The catalytic versatility can be understood by considering the chemical features of this cofactor. In recent years, exciting new reactions involving PLP have been discovered in natural products biosynthesis, upending our understanding of what this cofactor is capable of. Here we review some of the most exciting PLP-dependent reactions from the last five years.

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.