影响淀粉样蛋白纤维形成的因素

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Fereshteh Ramezani Khorsand, Fatemeh Aziziyan, Khosro Khajeh
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引用次数: 0

摘要

蛋白质的聚集是一个复杂的过程,分为几个阶段,最终形成复杂的结构和形状,其稳定性和毒性变化很大。聚集过程受到各种因素和环境条件的影响,这些因素和环境条件会破坏蛋白质的原始状态,包括突变、表达水平和多肽链截断等内部因素,以及密集的分子环境、翻译后修饰以及与其他蛋白质、核酸、小分子、金属离子、伴侣和脂膜的相互作用等外部因素。在聚集过程中,聚集蛋白质的生物活性可能会降低或消失,而产生的聚集体可能具有免疫原性,或具有其他不良特性。寻找蛋白质聚集的原因并将其控制在可接受的水平,是学术界和生物制药公司最重要的研究课题之一。本章旨在回顾蛋白质聚集的内在途径以及影响这一过程的潜在外在变量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Factors influencing amyloid fibril formation.

Protein aggregation is a complex process with several stages that lead to the formation of complex structures and shapes with a broad variability in stability and toxicity. The aggregation process is affected by various factors and environmental conditions that disrupt the protein's original state, including internal factors like mutations, expression levels, and polypeptide chain truncation, as well as external factors, such as dense molecular surroundings, post-translation modifications, and interactions with other proteins, nucleic acids, small molecules, metal ions, chaperones, and lipid membranes. During the aggregation process, the biological activity of an aggregating protein may be reduced or eliminated, whereas the resulting aggregates may have the potential to be immunogenic, or they may have other undesirable properties. Finding the cause(s) of protein aggregation and controlling it to an acceptable level is among the most crucial topics of research in academia and biopharmaceutical companies. This chapter aims to review intrinsic pathways of protein aggregation and potential extrinsic variables that influence this process.

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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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