{"title":"重度抑郁症患者的白质变化与临床症状之间的相关性","authors":"Fei Fei Zhao, Yi Chang Jin, Xin Liang Chen","doi":"10.1134/s181971242402017x","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>To analyse the structural characteristics and fibre integrity of white matter in patients with major depressive disorder (MDD) and its relationship with depressive symptoms. Patients with MDD admitted to Wenzhou Seventh People’ Hospital between September 2021 and May 2023 were recruited as participants in the experimental group, and healthy volunteers matching in gender, age and years of education were recruited during the same period as the control group. The two groups were compared in terms of fractional anisotropy (FA), mean diffusivity (MD) and axial diffusivity (AD). The relationship between the white matter volume and the values of FA, MD and AD in different brain regions and the severity of depressive symptoms in the experimental group was analysed. Fifty-eight patients were included in the experimental group, and 60 healthy controls in the control group. In the experimental group, the white matter volume of the right inferior frontal gyrus was negatively correlated with the Hamilton depression rating scale (HAMD-17) score (<i>r</i> = ‒0.355, <i>P</i> < 0.05), and the left parietal gyrus was negatively correlated with the HAMD-17 score (<i>r</i> = –0.361, <i>P</i> < 0.05). The FA value in the occipital radiations of the corpus callosum of the white matter was negatively correlated with the HAMD-17 score (<i>r</i> = –0.410, <i>P</i> < 0.05). Moreover, the MD value of the left and right anterior thalamic radiation of white matter was negatively correlated with the HAMD-17 score (<i>r</i> = –0.389, <i>P</i> < 0.05; <i>r</i> = –0.489, <i>P</i> < 0.01, respectively), and the AD value showed a negative correlation with the HAMD-17 score (<i>r</i> = –0.446, –0.405, respectively, both <i>P</i> < 0.05). Patients with MDD suffer from decreased white matter volume and impaired fibre integrity of white matter, including in the parietal lobe, corpus callosum, corticospinal tract and inferior longitudinal tract. Abnormalities in white matter structure and fibre integrity have a close bearing on the severity of MDD.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlation between White Matter Changes and Clinical Symptoms in Patients with Major Depressive Disorder\",\"authors\":\"Fei Fei Zhao, Yi Chang Jin, Xin Liang Chen\",\"doi\":\"10.1134/s181971242402017x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Abstract</h3><p>To analyse the structural characteristics and fibre integrity of white matter in patients with major depressive disorder (MDD) and its relationship with depressive symptoms. Patients with MDD admitted to Wenzhou Seventh People’ Hospital between September 2021 and May 2023 were recruited as participants in the experimental group, and healthy volunteers matching in gender, age and years of education were recruited during the same period as the control group. The two groups were compared in terms of fractional anisotropy (FA), mean diffusivity (MD) and axial diffusivity (AD). The relationship between the white matter volume and the values of FA, MD and AD in different brain regions and the severity of depressive symptoms in the experimental group was analysed. Fifty-eight patients were included in the experimental group, and 60 healthy controls in the control group. In the experimental group, the white matter volume of the right inferior frontal gyrus was negatively correlated with the Hamilton depression rating scale (HAMD-17) score (<i>r</i> = ‒0.355, <i>P</i> < 0.05), and the left parietal gyrus was negatively correlated with the HAMD-17 score (<i>r</i> = –0.361, <i>P</i> < 0.05). The FA value in the occipital radiations of the corpus callosum of the white matter was negatively correlated with the HAMD-17 score (<i>r</i> = –0.410, <i>P</i> < 0.05). Moreover, the MD value of the left and right anterior thalamic radiation of white matter was negatively correlated with the HAMD-17 score (<i>r</i> = –0.389, <i>P</i> < 0.05; <i>r</i> = –0.489, <i>P</i> < 0.01, respectively), and the AD value showed a negative correlation with the HAMD-17 score (<i>r</i> = –0.446, –0.405, respectively, both <i>P</i> < 0.05). Patients with MDD suffer from decreased white matter volume and impaired fibre integrity of white matter, including in the parietal lobe, corpus callosum, corticospinal tract and inferior longitudinal tract. Abnormalities in white matter structure and fibre integrity have a close bearing on the severity of MDD.</p>\",\"PeriodicalId\":19119,\"journal\":{\"name\":\"Neurochemical Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2024-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurochemical Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1134/s181971242402017x\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1134/s181971242402017x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Correlation between White Matter Changes and Clinical Symptoms in Patients with Major Depressive Disorder
Abstract
To analyse the structural characteristics and fibre integrity of white matter in patients with major depressive disorder (MDD) and its relationship with depressive symptoms. Patients with MDD admitted to Wenzhou Seventh People’ Hospital between September 2021 and May 2023 were recruited as participants in the experimental group, and healthy volunteers matching in gender, age and years of education were recruited during the same period as the control group. The two groups were compared in terms of fractional anisotropy (FA), mean diffusivity (MD) and axial diffusivity (AD). The relationship between the white matter volume and the values of FA, MD and AD in different brain regions and the severity of depressive symptoms in the experimental group was analysed. Fifty-eight patients were included in the experimental group, and 60 healthy controls in the control group. In the experimental group, the white matter volume of the right inferior frontal gyrus was negatively correlated with the Hamilton depression rating scale (HAMD-17) score (r = ‒0.355, P < 0.05), and the left parietal gyrus was negatively correlated with the HAMD-17 score (r = –0.361, P < 0.05). The FA value in the occipital radiations of the corpus callosum of the white matter was negatively correlated with the HAMD-17 score (r = –0.410, P < 0.05). Moreover, the MD value of the left and right anterior thalamic radiation of white matter was negatively correlated with the HAMD-17 score (r = –0.389, P < 0.05; r = –0.489, P < 0.01, respectively), and the AD value showed a negative correlation with the HAMD-17 score (r = –0.446, –0.405, respectively, both P < 0.05). Patients with MDD suffer from decreased white matter volume and impaired fibre integrity of white matter, including in the parietal lobe, corpus callosum, corticospinal tract and inferior longitudinal tract. Abnormalities in white matter structure and fibre integrity have a close bearing on the severity of MDD.
期刊介绍：
Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components.
The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.
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