Baohang Lin, Xun Peng, Jianjun Cheng and Jiacheng Wang
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引用次数: 0
摘要
甘草酸(GA)作为一种天然衍生的化疗药物,在抗肿瘤治疗中越来越受到关注。然而,目前的研究主要集中在改善其药理特性,以克服临床应用中的不足,或将其作为一种与化疗和化学光疗相结合的协同抗癌剂。然而,GA 的材料特性(如自组装)往往被忽视。在此,我们以吡咯并烯酮-a(PPa)为药物模型,验证了天麻的自组装功能及其作为单组分活性载体协同递送的巨大潜力。结果表明,自组装的 GA 主要通过π-π堆积、疏水作用和氢键等非共价相互作用推动纳米-GA/PPa 的形成。此外,虽然单独体外化疗和联合化学光疗在细胞毒性方面没有发现明显差异,但制备的纳米GA/PPa表现出显著的水溶性和多种有利的治疗特性,从而使体内光化学疗法的抑制率达到89.3%,并降低了GA的肝毒性。这项工作凸显了自组装 GA 作为药物递送载体在协同生物医学应用方面的潜力。
Natural gambogic acid-tuned self-assembly of nanodrugs towards synergistic chemophototherapy against breast cancer†
Gambogic acid (GA) as a naturally derived chemotherapeutic agent is of increasing interest for antitumor therapy. However, current research mainly focuses on improving the pharmacological properties to overcome the shortcomings in clinical applications or as a synergistic anticancer agent in combination with chemotherapy and chemophototherapy. Yet, the material properties of GA (e.g., self-assembly) are often neglected. Herein, we validated the self-assembly function of GA and its huge potential as a single-component active carrier for synergistic delivery using pyropheophorbide-a (PPa) as a drug model. The results showed that self-assembled GA drives the formation of nano-GA/PPa mainly through noncovalent interactions such as π–π stacking, hydrophobic interactions, and hydrogen bonding. Additionally, although no significant differences in cytotoxicity were found between the individual in vitro chemotherapy and combined chemophototherapy, the as-prepared nano-GA/PPa exhibits remarkably improved water solubility and multiple favorable therapeutic features, leading to a prominent in vivo photochemotherapy efficiency of 89.3% inhibition rate with reduced hepatotoxicity of GA. This work highlights the potential of self-assembled GA as a drug delivery carrier for synergistic biomedical applications.
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices