氧化应激与神经退行性变:帕金森病的见解和治疗策略》。

IF 3.2 Q2 CLINICAL NEUROLOGY
Erjola Bej, Patrizia Cesare, Anna Rita Volpe, Michele d'Angelo, Vanessa Castelli
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引用次数: 0

摘要

帕金森病(PD)是一种进行性神经退行性疾病,其特征是黑质中的多巴胺能神经元逐渐退化。近年来的研究发现,氧化应激是导致帕金森病发展的一个关键因素。在第一部分中,我们讨论了帕金森病氧化应激的来源,包括线粒体功能障碍、多巴胺代谢和神经炎症。本文深入探讨了减轻氧化应激作为一种潜在治疗方法的可能性。此外,我们还研究了抗氧化疗法的障碍和潜力,包括将抗氧化剂输送到大脑所面临的挑战,以及追踪帕金森病患者氧化应激的生物标记物的要求。然而,即使抗氧化疗法前景广阔,仍需进一步研究以确定其在帕金森病治疗中的有效性和安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxidative Stress and Neurodegeneration: Insights and Therapeutic Strategies for Parkinson's Disease.

Parkinson's disease (PD) is a progressive neurodegenerative condition marked by the gradual deterioration of dopaminergic neurons in the substantia nigra. Oxidative stress has been identified as a key player in the development of PD in recent studies. In the first part, we discuss the sources of oxidative stress in PD, including mitochondrial dysfunction, dopamine metabolism, and neuroinflammation. This paper delves into the possibility of mitigating oxidative stress as a potential treatment approach for PD. In addition, we examine the hurdles and potential of antioxidant therapy, including the challenge of delivering antioxidants to the brain and the requirement for biomarkers to track oxidative stress in PD patients. However, even if antioxidant therapy holds promise, further investigation is needed to determine its efficacy and safety in PD treatment.

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来源期刊
Neurology International
Neurology International CLINICAL NEUROLOGY-
CiteScore
3.70
自引率
3.30%
发文量
69
审稿时长
11 weeks
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