自体免疫疾病的重要调节因子 miRNA-21

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current molecular medicine Pub Date : 2024-05-27 DOI:10.2174/0115665240290075240514164601

Roghayeh Tofigh, Reza Safaralizadeh, Mohammadali Hosseinpourfeizi, Nima Hemmat, Behzad Baradaran

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引用次数: 0

摘要

miRNA-21 被认为是微RNA（miRNA）家族中含量丰富且高度保守的成员。它几乎在每个细胞中都有表达，负责对健康和疾病有重要影响的关键调节作用。这种 microRNA 已被证明可能在多种免疫相关疾病的发病机制中发挥作用，其中包括自身免疫性疾病，如多发性硬化症和系统性红斑狼疮，这两种疾病就是可能与之有关的突出例子。在目前的研究中，我们研究了 miRNA-21 的作用，它被认为是最重要的致病 miRNA 之一，在自身免疫性疾病的发展中起着重要作用。

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miRNA-21, an Important Regulator of Autoimmune Diseases.

miRNA-21 is regarded as both an abundant and highly conserved member of the microRNA (miRNA) family. It is expressed in virtually every cell and is responsible for critical regulatory actions that are important in health and disease. This microRNA has been shown to potentially have a role in the pathogenesis of several immune-related disorders, including autoimmune diseases, such as Multiple sclerosis and systemic lupus erythematosus, as two prominent examples of diseases that might be involved. In the current research, we looked at the role of miRNA-21, regarded as one of the most significant pathogenic miRNAs with a role in the development of autoimmune illness.

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来源期刊

Current molecular medicine 医学-医学：研究与实验

CiteScore

5.00

自引率

4.00%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews/ mini-reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.