白细胞介素-1β基因多态性对肝细胞癌门静脉微小浸润和预后的影响

IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Yosuke Namba, Tsuyoshi Kobayashi, Takeshi Tadokoro, Sotaro Fukuhara, Ko Oshita, Keiso Matsubara, Naruhiko Honmyo, Shintaro Kuroda, Masahiro Ohira, Hideki Ohdan
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引用次数: 0

摘要

背景:多项研究表明,白细胞介素-1β(IL-1β)的基因多态性与癌症的发生发展有一定关系,但其对癌症预后的影响尚不清楚。本研究旨在评估 IL-1β 单核苷酸多态性对肝细胞癌血行播散和预后的影响:我们进行了一项回顾性队列研究,研究对象包括2015年4月至2018年12月期间在我院接受原发性肝切除术的肝细胞癌患者。主要终点为总生存期和无复发生存期。次要终点为显微门静脉侵犯和循环肿瘤细胞数量:共纳入148例患者,其中32例具有rs16944 A/A基因型。A/A 基因型与显微门静脉侵犯和循环肿瘤细胞数量相关(p = .03 和 .04)。在多变量分析中,A/A 基因型、甲胎蛋白水平和循环肿瘤细胞数量与微小门静脉侵犯相关(p = .01、.01 和结论:我们的研究结果表明,IL-1β rs16944 A/A 基因型与循环肿瘤细胞数量、显微门静脉侵犯和 HCC 预后有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of genetic polymorphisms of interleukin-1 beta on the microscopic portal vein invasion and prognosis of hepatocellular carcinoma

Effect of genetic polymorphisms of interleukin-1 beta on the microscopic portal vein invasion and prognosis of hepatocellular carcinoma

Background

Several studies have demonstrated a relationship between genetic polymorphisms of interleukin-1 beta (IL-1β) and cancer development; however, their influence on cancer prognosis is unknown. In the present study, we aimed to evaluate the impact of IL-1β single nucleotide polymorphisms on the hematogenous dissemination and prognosis of hepatocellular carcinoma.

Methods

We conducted a retrospective cohort study including patients with hepatocellular carcinoma who underwent primary liver resection at our hospital between April 2015 and December 2018. The primary endpoints were overall and recurrence-free survival. Secondary endpoints were microscopic portal vein invasion and number of circulating tumor cells.

Results

A total of 148 patients were included, 32 with rs16944 A/A genotype. A/A genotype was associated with microscopic portal vein invasion and number of circulating tumor cells (p = .03 and .04). In multivariate analysis, A/A genotype, alpha-fetoprotein level, and number of circulating tumor cells were associated with microscopic portal vein invasion (p = .01, .01, and <.01). A/A genotype, Child-Pugh B, and intraoperative blood loss were independent predictive factors for overall survival (p = .02, <.01, and <.01).

Conclusions

Our results indicate that the IL-1β rs16944 A/A genotype is involved in number of circulating tumor cells, microscopic portal vein invasion, and prognosis in HCC.

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来源期刊
Journal of Hepato‐Biliary‐Pancreatic Sciences
Journal of Hepato‐Biliary‐Pancreatic Sciences GASTROENTEROLOGY & HEPATOLOGY-SURGERY
自引率
10.00%
发文量
178
审稿时长
6-12 weeks
期刊介绍: The Journal of Hepato-Biliary-Pancreatic Sciences (JHBPS) is the leading peer-reviewed journal in the field of hepato-biliary-pancreatic sciences. JHBPS publishes articles dealing with clinical research as well as translational research on all aspects of this field. Coverage includes Original Article, Review Article, Images of Interest, Rapid Communication and an announcement section. Letters to the Editor and comments on the journal’s policies or content are also included. JHBPS welcomes submissions from surgeons, physicians, endoscopists, radiologists, oncologists, and pathologists.
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