亚砷酸钠通过下调 ZMYND15 和 ZMYND10 影响精子质量。

IF 4.4 3区 医学 Q2 ENVIRONMENTAL SCIENCES
Xiangli Li, Kaina Shen, Dunxuan Yuan, Xi Li, Jinrou Quan, Fangzhou Tian, Yan Yang, Li Zhang, Junling Wang
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引用次数: 0

摘要

据记载,锌指 MYND 型含 15(ZMYND15)在精子发生过程中发挥重要作用,突变体可导致隐性无精子症、严重少精子症、非梗阻性无精子症、畸形无精子症,甚至男性不育。ZMYND10 与精子活力有关。至于环境污染物是否会通过调节 ZMYND15 和 ZMYND10 的表达来损害男性生育能力,目前尚无研究。砷暴露会导致精子质量差和男性不育。为了研究砷诱导的雄性生殖毒性是否与 ZMYND15、ZMYND10 及其靶基因的表达有关,我们建立了亚砷酸钠暴露诱导的雄性大鼠生殖损伤模型,测定了精子质量、血清激素水平、睾丸内 ZMYND15 和 ZMYND10 及其靶基因的 mRNA 和蛋白表达。结果表明,与对照组相比,亚砷酸钠暴露除了增加了 Tnp1 的 mRNA 表达量外,还降低了雄性大鼠的精子质量、血清激素水平、睾丸内 ZMYND15 和 ZMYND10 及其靶基因的 mRNA 和蛋白表达量(p<0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sodium arsenite impairs sperm quality via downregulating the ZMYND15 and ZMYND10

Zinc finger MYND-type containing 15 (ZMYND15) has been documented to play important roles in spermatogenesis, and mutants contribute to recessive azoospermia, severe oligozoospermia, non-obstructive azoospermia, teratozoospermia, even male infertility. ZMYND10 is involved in sperm motility. Whether environmental pollutants impair male fertility via regulating the expression of ZMYND15 and ZMYND10 has not been studied. Arsenic exposure results in poor sperm quality and male infertility. In order to investigate whether arsenic-induced male reproductive toxicity is related to the expression of ZMYND15, ZMYND10 and their target genes, we established a male rat model of sodium arsenite exposure-induced reproductive injury, measured sperm quality, serum hormone levels, mRNA and protein expressions of intratesticular ZMYND15 and ZMYND10 as well as their target genes. The results showed that, in addition to the increased mRNA expression of Tnp1, sodium arsenite exposure reduced sperm quality, serum hormone levels, and mRNA and protein expression of intratesticular ZMYND15 and ZMYND10 and their target genes in male rats compared with the control group (p < .05). Therefore, our study first showed that the environmental pollutant arsenic impairs sperm quality in male rats by reducing the expression of ZMYND10 and ZMYND15 and their regulatory genes, which provides a possible diagnostic marker for environmental pollutants-induced male infertility.

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来源期刊
Environmental Toxicology
Environmental Toxicology 环境科学-毒理学
CiteScore
7.10
自引率
8.90%
发文量
261
审稿时长
4.5 months
期刊介绍: The journal publishes in the areas of toxicity and toxicology of environmental pollutants in air, dust, sediment, soil and water, and natural toxins in the environment.Of particular interest are: Toxic or biologically disruptive impacts of anthropogenic chemicals such as pharmaceuticals, industrial organics, agricultural chemicals, and by-products such as chlorinated compounds from water disinfection and waste incineration; Natural toxins and their impacts; Biotransformation and metabolism of toxigenic compounds, food chains for toxin accumulation or biodegradation; Assays of toxicity, endocrine disruption, mutagenicity, carcinogenicity, ecosystem impact and health hazard; Environmental and public health risk assessment, environmental guidelines, environmental policy for toxicants.
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