乌拉圭住院病人的静脉血栓栓塞风险和药物预防血栓的依从性:首次全国性研究。

IF 2.3 4区 医学 Q2 HEMATOLOGY
Valentina Mérola, Ana Carina Pizzarossa, Maynés López, Franco Peverelli, Gustavo Bruno, Mariana González, Federico Roca, Leticia Dentone, Gerardo Pérez, Lucía Da Silveira, Lilián Díaz, Josefina Tafuri, Rosario Cuadro, Martín Zaquiere, Guillermina Bartaburu, Franco Pacello, Carina Celio, María José López, Marcelo Viana, Laura Fraga, Valeria Blanco, Paula Chalart, Daniel Leal, Xilef Rodríguez, Laura Teti, Carolina Goñi, Eduardo Infante, Alejandra Prícoli, Victoria Altieri, Cecilia Guillermo, Rosario Martínez
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引用次数: 0

摘要

导言:静脉血栓栓塞症(VTE)是住院病人中一种严重、常见且可预防的医疗并发症。虽然预防性治疗(药物和/或机械)的疗效已得到证实,但在国际和国内层面上,预防性治疗的依从性却很差。目的:确定乌拉圭住院患者药物血栓预防的适应症和使用情况:方法:进行了一项观察性、描述性、横断面、多中心研究,涉及全国 31 家医疗机构。研究评估了与入院相关的基线特征、有血栓预防指征的人口比例以及接受药物血栓预防的患者比例。对内科患者采用帕多瓦评分,对外科患者采用卡普里尼评分,对妊娠-产后患者采用英国皇家妇产科医师学会(RCOG)指南来确定VTE风险:共纳入 1925 名患者,占乌拉圭住院患者的 26%。71.9%的患者有 VTE 风险。在所有有 VTE 风险的患者中,58.6% 接受了药物血栓预防治疗。未接受血栓预防药物治疗的原因包括:16.1%的患者存在处方遗漏,15.9%的患者存在禁忌症,9.4%的患者因其他原因已接受抗凝治疗。总体而言,仅有 68% 的患者得到了预防 VTE 的 "保护"。70.1%的高危患者遵循了主要血栓预防指南的建议:尽管在遵守血栓预防指征方面取得了进展,但不遵守指征仍然是一个问题,在乌拉圭,每六名 VTE 高危患者中就有一人受到影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Venous Thromboembolism Risk and Adherence to Pharmacological Thromboprophylaxis in Hospitalized Patients in Uruguay: First Nationwide Study.

Introduction: Venous thromboembolism (VTE) is a serious, frequent, and preventable medical complication in hospitalized patients. Although the efficacy of prophylaxis (pharmacological and/or mechanical) has been demonstrated, compliance with prophylaxis is poor at international and national levels.

Aim: To determine the indication and use of pharmacological thromboprophylaxis in hospitalized patients in Uruguay.

Methods: An observational, descriptive, cross-sectional, multicentre study involving 31 nationwide healthcare facilities was conducted. Baseline characteristics associated with hospital admission, the percentage of the population with an indication for thromboprophylaxis, and the percentage of patients receiving pharmacological thromboprophylaxis were assessed. The VTE risk was determined using the Padua score for medical patients; the Caprini score for surgical patients; the Royal College of Obstetricians and Gynaecologists (RCOG) guidelines for pregnant-postpartum patients.

Results: 1925 patients were included, representing 26% of hospitalized patients in Uruguay. 71.9% of all patients were at risk of VTE. Of all patients at risk of VTE, 58.6% received pharmacological thromboprophylaxis. The reasons for not receiving thromboprophylaxis were prescribing omissions in 16.1% of cases, contraindication in 15.9% and 9.4% of patients were already anticoagulated for other reasons. Overall, just 68% of patients were "protected" against VTE. Recommendations of major thromboprophylaxis guidelines were followed in 70.1% of patients at risk.

Conclusions: Despite the progress made in adherence to thromboprophylaxis indications, nonadherence remains a problem, affecting one in six patients at risk of VTE in Uruguay.

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来源期刊
CiteScore
4.40
自引率
3.40%
发文量
150
审稿时长
2 months
期刊介绍: CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.
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