聚焦超声介导的血脑屏障开放治疗阿尔茨海默病的安全性、有效性和临床应用：系统综述

IF 4.3 Q2 BUSINESS

The Journal of Prevention of Alzheimer's Disease Pub Date : 2024-05-22 DOI:10.14283/jpad.2024.85

A. Patwardhan, T. Wilkinson, Y. Meng, I. Alhashyan, S. E. Black, N. Lipsman, Mario Masellis

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引用次数: 0

摘要

阿尔茨海默病是一种神经退行性疾病，以认知能力下降和涉及淀粉样蛋白斑块和神经纤维缠结的脑部病理变化为特征。目前的药物开发主要集中在改变病情的疗法上，主要是针对淀粉样蛋白或 tau 的抗体。然而，血脑屏障（BBB）给药物进入大脑带来了挑战。前期和早期临床数据表明，聚焦超声（FUS）技术能在不损伤脑组织的情况下安全地增强血脑屏障的通透性，从而实现药物输送。本系统综述讨论了应用 FUS 打开 BBB 以治疗阿尔茨海默病（AD）的情况。我们回顾了 FUS 介导的打开阿尔茨海默病患者 BBB 的安全性、有效性和潜在生物效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Safety, Efficacy and Clinical Applications of Focused Ultrasound-Mediated Blood Brain Barrier Opening in Alzheimer’s Disease: A Systematic Review

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Safety, Efficacy and Clinical Applications of Focused Ultrasound-Mediated Blood Brain Barrier Opening in Alzheimer’s Disease: A Systematic Review

Alzheimer’s disease is a neurodegenerative disorder marked by cognitive decline and brain pathology involving amyloid plaques and neurofibrillary tangles. Current drug development focuses on disease-modifying therapies, primarily antibodies targeting amyloid or tau. However, the blood-brain barrier (BBB) poses a challenge for drug delivery to the brain. Pre-and early clinical data suggests that Focused Ultrasound (FUS) technology safely enhances BBB permeability without damaging brain tissue, enabling drug delivery. This systematic review discusses the application of FUS to open the BBB for the treatment of Alzheimer’s disease (AD). We review the safety, efficacy, and potential biological effects of FUS-mediated BBB opening in AD patients.

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来源期刊

The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health

CiteScore

9.20

自引率

0.00%

发文量

期刊介绍： The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.