Formulation and evaluation of mouth-dissolving films of memantine

This present research aims to formulate and evaluate mouth dissolving films using Memantine as model drug to improve bioavailability and facilitate rapid onset of action to relieve vomiting and nausea. The thicknesses of the films were in the range of 0.234 mm to 0.271mm. The weights of the films were found to be in the range of ±10%. The folding endurance of the films was found to be in the range of 38± 1 to 57 ± 2.  The surface pHs of all the films were neutral, as there was no color change in the litmus paper.  All the films were found to be 98 to 102. The disintegration time of the prepared films ranged from 21sec to 32sec. Acceptable mechanical properties were obtained in batch F-9, and the in vitro disintegration time was below 27 sec. It has been determined that formulations F-9 were found to be satisfactory batches and were optimized for the desirable properties.