萨摩亚人的老年认知优势与 CREBRF 变体 rs373863828 有关

GeroPsych Pub Date : 2024-05-22 DOI:10.1024/1662-9647/a000338

B. Levy, S. Viali, T. Naseri, M. Reupena, Kima Faasalele-Savusa, Vaimoana Filipo, Erin E. Kershaw, Yuan Huang, Martin D. Slade

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引用次数: 0

摘要

摘要：我们研究了 CREBRF rs373863828 的 A 等位基因（在萨摩亚人中常见但在非太平洋岛民中罕见）是否能预测更好的认知能力。萨摩亚访问员采访了年龄在 60 岁及以上、居住在萨摩亚独立国并有四个萨摩亚祖父母的参与者。在效应大小分析中，AA 基因型能显著预测萨摩亚老年人更好的主观和客观认知能力；它对主观认知能力的贡献是 APOE 的 5.9 倍，对客观认知能力的贡献是 APOE 的 12.3 倍。由于CREBRF在通用的CREB系统中运行，因此研究结果可以为一般的衰老-认知复原力提供参考。

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Advantage in Aging Cognition Associated with the CREBRF variant rs373863828 Among Samoans

Abstract: We examined whether the A allele of CREBRF rs373863828, which is common in Samoans but rare in non-Pacific Islanders, predicts better cognition. Samoan interviewers interviewed participants who were 60 years and older, lived in the Independent State of Samoa, and had four Samoan grandparents. The AA genotype significantly predicted older Samoans’ better subjective and objective cognition; it also contributed 5.9 times more than APOE to subjective cognition and 12.3 times more than APOE to objective cognition, in effect-size analyses. Since CREBRF operates in the universal CREB system, the findings could inform general aging-cognition resilience.

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GeroPsych

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