{"title":"使用新的血清素摄取抑制剂[3H]帕罗西汀测量血清素摄取部位。","authors":"C H Gleiter, D J Nutt","doi":"10.1300/J251v07n03_17","DOIUrl":null,"url":null,"abstract":"<p><p>Serotonin is an important neurotransmitter that may be involved in ethanol preference and dependence. It is possible to label the serotonin uptake site in brain using the tricyclic antidepressant imipramine, but this also binds to other sites. We have used the new high-affinity uptake blocker paroxetine to define binding to this site and report it to have advantages over imipramine as a ligand.</p>","PeriodicalId":77481,"journal":{"name":"Advances in alcohol & substance abuse","volume":"7 3-4","pages":"107-11"},"PeriodicalIF":0.0000,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1300/J251v07n03_17","citationCount":"0","resultStr":"{\"title\":\"Measuring the serotonin uptake site using [3H]paroxetine--a new serotonin uptake inhibitor.\",\"authors\":\"C H Gleiter, D J Nutt\",\"doi\":\"10.1300/J251v07n03_17\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Serotonin is an important neurotransmitter that may be involved in ethanol preference and dependence. It is possible to label the serotonin uptake site in brain using the tricyclic antidepressant imipramine, but this also binds to other sites. We have used the new high-affinity uptake blocker paroxetine to define binding to this site and report it to have advantages over imipramine as a ligand.</p>\",\"PeriodicalId\":77481,\"journal\":{\"name\":\"Advances in alcohol & substance abuse\",\"volume\":\"7 3-4\",\"pages\":\"107-11\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1300/J251v07n03_17\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in alcohol & substance abuse\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1300/J251v07n03_17\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in alcohol & substance abuse","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1300/J251v07n03_17","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Measuring the serotonin uptake site using [3H]paroxetine--a new serotonin uptake inhibitor.
Serotonin is an important neurotransmitter that may be involved in ethanol preference and dependence. It is possible to label the serotonin uptake site in brain using the tricyclic antidepressant imipramine, but this also binds to other sites. We have used the new high-affinity uptake blocker paroxetine to define binding to this site and report it to have advantages over imipramine as a ligand.
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