EBV阳性结节性T细胞和NK细胞淋巴瘤模仿无弹性大细胞淋巴瘤：病例报告

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-23 DOI:10.3390/hematolrep16020031

B. Abro, Pamela Allen, Saja Asakrah, Kyle Bradley, Linsheng Zhang

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引用次数: 0

摘要

EBV 阳性结节性 T- 和 NK 细胞淋巴瘤（EBV+ NT/NKCL）是最近在第五版《世界卫生组织造血和淋巴组织肿瘤分类》（WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues）中被确认的一种实体。值得注意的是，在（EBV+ NT/NKCL）中经常观察到 CD30 阳性，这给将其与 ALK 阴性的无性大细胞淋巴瘤（ALCL）区分开来带来了诊断上的挑战。此外，EBV+ ALCL 的病例在文献中也有记载，这比将 EBV+结节细胞毒性 T 细胞淋巴瘤作为外周 T 细胞淋巴瘤的一种变体要早。我们报告了一例 47 岁男性多发淋巴结病例。淋巴结的组织形态学和免疫表型特征与 ALK 阴性 ALCL 非常相似，其特点是 CD30 表达一致，淋巴瘤细胞呈囊下分布。然而，淋巴瘤细胞表现出弥漫的EBV阳性，与EBV+ NT/NKCL一致。此外，还有一例ALK阴性ALCL，其免疫表型与EBV阳性病例完全相同，以作比较。与 ALK 阴性 ALCL 相比，EBV+ NT/NKCL 是一种侵袭性肿瘤，需要独特的临床治疗，因此准确区分 EBV+ NT/NKCL 和具有细胞毒性 T 细胞免疫表型的 ALK 阴性 ALCL 至关重要。

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EBV-Positive Nodal T- and NK-Cell Lymphoma Mimicking Anaplastic Large Cell Lymphoma: A Case Report

EBV-positive nodal T- and NK-cell lymphoma (EBV+ NT/NKCL) is a recently recognized entity in the 5th edition of the WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. Notably, CD30 positivity is frequently observed in (EBV+ NT/NKCL), creating diagnostic challenges to distinguish it from ALK-negative anaplastic large cell lymphoma (ALCL). Furthermore, cases of EBV+ ALCL have been documented in the literature, predating the inclusion of EBV+ nodal cytotoxic T-cell lymphoma as a variant of peripheral T-cell lymphoma. We present a case of a 47-year-old male presenting with multiple lymphadenopathies. The histomorphologic and immunophenotypic features of the lymph node closely resemble ALK-negative ALCL, characterized by uniform CD30 expression and a subcapsular distribution of lymphoma cells. However, the lymphoma cells exhibit diffuse positivity for EBV, consistent with EBV+ NT/NKCL. A case of ALK-negative ALCL with an immunophenotype identical to the EBV-positive case is included for comparison. Given that EBV+ NT/NKCL represents an aggressive neoplasm requiring unique clinical management compared to ALK-negative ALCL, it is critical to accurately differentiate EBV+ NT/NKCL from ALK-negative ALCL with a cytotoxic T-cell immunophenotype.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.