无间隙生物合成途径实现了紫杉醇的可持续生产。

IF 17.3 1区生物学 Q1 PLANT SCIENCES

Trends in Plant Science Pub Date : 2024-09-01 Epub Date: 2024-05-23 DOI:10.1016/j.tplants.2024.05.005

Chengfeng Xue, Meng Zhang, Ruifeng Yao

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引用次数: 0

摘要

Jiang 等人最近的一项前沿研究发现了两种酶，它们负责巴卡丁 III 生物合成过程中的关键反应。作者成功地在烟草叶片中用最少的合成酶重建了巴卡丁 III 的合成途径，为工业规模可持续生产抗癌药物紫杉醇奠定了基础。

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Gapless biosynthetic pathway enables sustainable paclitaxel production.

A recent leading-edge study by Jiang et al. identified two enzymes that are responsible for key reactions in the biosynthesis of baccatin III. The authors successfully reconstructed the baccatin III synthesis pathway with a minimal number of synthetic enzymes in tobacco leaves, laying the foundation for industrial-scale sustainable production of the anticancer drug paclitaxel.

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来源期刊

Trends in Plant Science 生物-植物科学

CiteScore

31.30

自引率

2.00%

发文量

196

审稿时长

6-12 weeks

期刊介绍： Trends in Plant Science is the primary monthly review journal in plant science, encompassing a wide range from molecular biology to ecology. It offers concise and accessible reviews and opinions on fundamental plant science topics, providing quick insights into current thinking and developments in plant biology. Geared towards researchers, students, and teachers, the articles are authoritative, authored by both established leaders in the field and emerging talents.