在黑猩猩(Pan troglodytes)中使用植入式循环记录器监测心律失常并评估针灸和激光疗法的效果。

Comparative medicine Pub Date : 2016-02-01
Elizabeth R Magden, Meg M Sleeper, Stephanie J Buchl, Rebekah A Jones, Erica J Thiele, Gregory K Wilkerson
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引用次数: 0

摘要

心血管疾病是圈养黑猩猩死亡的主要原因之一,通常与心肌纤维化有关,而心肌纤维化会增加心律失常的风险。在本病例报告中,我们介绍了一只 36 岁的雄性黑猩猩(Pan troglodytes),它被诊断为频发室性早搏(VPC)。我们为它植入了皮下可植入环路记录器,以持续监测心电图,从而在不受麻醉剂干扰的情况下评估它的心律失常。在最初使用抗心律失常药物胺碘酮治疗期间,他出现了血小板减少症,因此停药。在研究了治疗心律失常的其他潜在疗法后,考虑到针灸和激光疗法的积极效果以及在人体中没有不良副作用的报道,我们选择了针灸和激光疗法。我们在手腕上使用了两个著名的心脏针灸部位:PC6(心包6)和 HT7(心脏7),并通过植入式循环记录仪的心电图记录评估了治疗效果。虽然动物兴奋程度的周期性增加会带来混杂变量,导致数据出现一些变化,但针灸和激光疗法似乎降低了这只黑猩猩的平均 VPC/分钟次数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Use of an Implantable Loop Recorder in a Chimpanzee (Pan troglodytes) to Monitor Cardiac Arrhythmias and Assess the Effects of Acupuncture and Laser Therapy.

Cardiovascular disease is a leading cause of death in captive chimpanzees and is often associated with myocardial fibrosis, which increases the risk of cardiac arrhythmias. In this case report, we present a 36-y-old male chimpanzee (Pan troglodytes) diagnosed with frequent ventricular premature complexes (VPC). We placed a subcutaneous implantable loop recorder for continual ECG monitoring to assess his arrhythmias without the confounding effects of anesthetics. During his initial treatment with the antiarrhythmia medication amiodarone, he developed thrombocytopenia, and the drug was discontinued. After reviewing other potential therapies for the treatment of cardiac arrhythmias, we elected to try acupuncture and laser therapy in view of the positive results and the lack of adverse side effects reported in humans. We used 2 well-known cardiac acupuncture sites on the wrist, PC6 (pericardium 6) and HT7 (heart 7), and evaluated the results of the therapy by using the ECG recordings from the implantable loop recorder. Although periodic increases in the animal's excitement level introduced confounding variables that caused some variation in the data, acupuncture and laser therapy appeared to decrease the mean number of VPC/min in this chimpanzee.

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