选定医疗机构中临时用药的普遍性、范围和质量以及对药学实践的影响。

Innovations in pharmacy Pub Date : 2024-03-18 eCollection Date: 2024-01-01 DOI:10.24926/iip.v15i1.5971
Grace Lovia Allotey-Babington, Irene Akwo Kretchy, Esther Atiapa Asiedu, Maxine Kelly Amuakwa, Obedia Akwele Seaneke, Daniel Ankrah, Abredu Kwadwo Somuah, Agatha Dei Owusu-Nyamekye, Sarah Owusu-Ansah, Patrick Kwame Effah, Johnson Debrah, Edna Acheampomaa Nai, Emmanuel Owusu, William Lamptey, Isaac Julius Asiedu Gyekye, Henry Nettey
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引用次数: 0

摘要

背景:即用复方制剂是指在没有市售授权剂型的情况下,为个别病人配制药物。与注册药物不同,这些产品无需接受监管部门的各种质量检测。目前,加纳有关复方药物的数据不足或无法获得。有必要对数据进行整理,以用于影响政策和规范即用产品的配制。目的:确定加纳阿克拉选定医院中即刻配制的复方药物的普遍性、范围和质量。采用的方法:对选定医院药房开具的处方进行审查,以确定需要临时配制的要求以及配方的普遍性和范围。我们采购了三种最常用的复方药物,并使用倒平板法进行微生物污染测试,如果存在微生物,则进行差异测试。使用高效液相色谱法(HPLC)对有效成分进行含量分析。结果研究医院共收到 641 份申请,包括 49 种不同的即用产品。羟基脲、呋塞米和螺内酯混悬液是最常见的三种处方药。0-2 岁的患者占处方的大多数。结论仍有一部分患者依赖复方制剂来满足他们的用药需求。其中一家受访医院配制了 49 种不同的制剂。分析的产品样本质量良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence, Scope and Quality of Extemporaneous Medications in Selected Healthcare Facilities and Implications for Pharmacy Practice.

Background: Extemporaneous compounding is the preparation of medicines for individual patients when no commercially available authorized form exists. Unlike registered medications, these products are not subjected to various tests for quality by Regulatory Authorities. Data on compounded medications in Ghana is currently inadequate or unavailable. There is the need to collate data that can be used to influence policy and to regulate preparation of extemporaneous products. Aim: To establish the prevalence, scope and quality of extemporaneously compounded medicines at selected hospitals in Accra, Ghana. Methodology: Prescriptions presented at the pharmacies in selected hospitals were reviewed to determine the requests that needed to be extemporaneously prepared as well as the prevalence and the scope of formulations. Three of the most frequently compounded medications were procured and subjected to microbial contamination tests using the pour plate method followed by differential tests if microbes were present. Content analysis of the active ingredients was determined using High Performance Liquid Chromatography (HPLC). Results: 641 requests comprising 49 different extemporaneous products were collated from the hospitals studied. Hydroxyurea, furosemide and spironolactone suspensions were the three most frequently prescribed. Patients aged from 0-2 years had majority of the prescriptions. Conclusion: A population of patients still exist who depend on compounding for their drug needs. 49 different formulations were prepared at one of the hospitals visited. Samples of products analyzed were of good quality.

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