维生素 D 和免疫系统

Q1 Agricultural and Biological Sciences

Advances in Food and Nutrition Research Pub Date : 2024-01-01 Epub Date: 2024-03-06 DOI:10.1016/bs.afnr.2023.12.001

Geoffrey Brown, Aleksandra Marchwicka, Ewa Marcinkowska

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引用次数: 0

摘要

众所周知，维生素 D 的活性代谢产物 1,25（OH）2D 具有调节人体钙磷平衡的作用。然而，1,25(OH)2D 的免疫调节活性早已为人所知。大量报告显示，血清中维生素 D 含量低与自身免疫性疾病的发病和急性感染的严重过程有关。在本章中，我们将探讨 1,25（OH）2D 在这些疾病中的作用，并讨论 1,25（OH）2D 在免疫细胞中的可能作用机制。

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Vitamin D and immune system.

The active metabolite of vitamin D 1,25(OH)₂D is well known for its role in regulating calcium-phosphate homeostasis of the human body. However, the immunomodulating activity of 1,25(OH)₂D has been known for many years. There are numerous reports correlating low vitamin D levels in blood serum with the onset of autoimmune diseases and with the severe course of acute infections. In this chapter, we address the role of 1,25(OH)₂D in these diseases, and we discuss the possible mechanisms of action of 1,25(OH)₂D in immune cells.

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来源期刊

Advances in Food and Nutrition Research Agricultural and Biological Sciences-Food Science

CiteScore

8.50

自引率

0.00%

发文量