抗菌肽对细菌膜曲率的影响，反之亦然。

IF 14 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Microbiology Pub Date : 2024-07-01 Epub Date: 2024-05-21 DOI:10.1016/j.tim.2024.04.012

Marlon H Cardoso, Cesar de la Fuente-Nunez, Nuno C Santos, Michael A Zasloff, Octávio L Franco

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引用次数: 0

摘要

导致细菌膜稳定的因素有很多，包括脂质之间的立体效应、膜自发曲率以及相邻分子数量的差异。本论坛概述了与膜曲率相关的物理化学特性，以及如何调整这一参数以设计出更有效的抗菌肽。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Influence of antimicrobial peptides on the bacterial membrane curvature and vice versa.

Many factors contribute to bacterial membrane stabilization, including steric effects between lipids, membrane spontaneous curvature, and the difference in the number of neighboring molecules. This forum provides an overview of the physicochemical properties associated with membrane curvature and how this parameter can be tuned to design more effective antimicrobial peptides.

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来源期刊

Trends in Microbiology 生物-生化与分子生物学

CiteScore

25.30

自引率

0.60%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.