核糖体 DNA 与神经系统疾病。

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current molecular medicine Pub Date : 2024-05-21 DOI:10.2174/0115665240292079240513093708

Hong Zhou, Yuqing Xia, Rui Zhu, Yuemei Zhang, Xinming Zhang, Yongjian Zhang, Jun Wang

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引用次数: 0

摘要

核糖体 DNA（rDNA）对人类细胞的核仁和核组织非常重要。据报道，rDNA重复维持缺陷与阿尔茨海默病、亨廷顿病、帕金森病、肌萎缩侧索硬化症、额颞叶痴呆症、抑郁症、自杀等神经系统疾病密切相关。然而，目前还没有关于 rDNA 在这些疾病中的作用的全面综述。在这篇综述中，我们总结了 rDNA 在主要神经系统疾病中的作用，梳理了 rDNA 与神经系统疾病的相关性，并为以 rDNA 为靶点的治疗提供了启示。

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Ribosomal DNA and Neurological Disorders.

Ribosomal DNA (rDNA) is important in the nucleolus and nuclear organization of human cells. Defective rDNA repeat maintenance has been reported to be closely associated with neurological disorders, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia, depression, suicide, etc. However, there has not been a comprehensive review on the role of rDNA in these disorders. In this review, we have summarized the role of rDNA in major neurological disorders to sort out the correlation between rDNA and neurological diseases and provided insights for therapy with rDNA as a target.

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来源期刊

Current molecular medicine 医学-医学：研究与实验

CiteScore

5.00

自引率

4.00%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews/ mini-reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.