丰坦相关肝病的单细胞多组学图谱

IF 45.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-05-21 DOI:10.1038/s41575-024-00944-x

Katrina Ray

引用次数: 0

摘要

丰坦手术是一种针对单心室先天性心脏病的重建手术。该手术通常在儿童早期进行，通常会导致多种内脏器官并发症，包括肝纤维化或丰坦相关性肝病（FALD）。然而，FALD的潜在机制尚不清楚，而且被认为有别于其他形式的肝纤维化疾病。最近的一项研究在单细胞水平上生成了人类FALD的转录组和表观基因组图谱，为FALD的发病机制提供了重要见解。在Fontan循环患者（n = 4，2-3岁时接受Fontan手术，13-18岁时作为青少年获得肝活检样本）肝脏的各种细胞类型中观察到了深刻的转录组和表观基因组变化。值得注意的是，中央肝细胞的变化最为显著，包括代谢重编程。这些中央肝细胞的变化先于肝星状细胞的激活和肝纤维化。研究还发现了一个配体-受体网络，该网络参与了从中央肝细胞到肝星状细胞的信号传导，体外研究表明，激活素 A 和 B 促进了肝纤维化的激活。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A single-cell multiomics profile of Fontan-associated liver disease

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.