猪是心血管研究的最佳动物模型

IF 5.9 3区农林科学 Q1 VETERINARY SCIENCES

Lab Animal Pub Date : 2024-05-21 DOI:10.1038/s41684-024-01377-4

Hao Jia, Yuan Chang, Jiangping Song

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引用次数: 0

摘要

心血管疾病是世界性的健康问题，也是发病和死亡的主要原因。临床前心血管研究需要使用动物来探索潜在的靶点和治疗方案。与啮齿类动物相比，猪具有许多优势，其解剖、生理、新陈代谢和免疫系统与人类更为相似。在此，我们概述了现有的心血管疾病猪模型，讨论了它们与其他模型相比的优势，并提出了标准化模型的概念，以改善向临床的转化并控制研究成本。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The pig as an optimal animal model for cardiovascular research

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The pig as an optimal animal model for cardiovascular research

Cardiovascular disease is a worldwide health problem and a leading cause of morbidity and mortality. Preclinical cardiovascular research using animals is needed to explore potential targets and therapeutic options. Compared with rodents, pigs have many advantages, with their anatomy, physiology, metabolism and immune system being more similar to humans. Here we present an overview of the available pig models for cardiovascular diseases, discuss their advantages over other models and propose the concept of standardized models to improve translation to the clinical setting and control research costs. This Review discusses the use of pig models in animal research for cardiovascular diseases, highlighting their advantages over rodent models and suggesting the need for standardized models to enhance clinical translation and target potential treatments.

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来源期刊

Lab Animal 农林科学-兽医学

CiteScore

0.60

自引率

2.90%

发文量

181

审稿时长

>36 weeks

期刊介绍： LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.