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引用次数: 0
摘要
植物基因的精确定向调控对于改善植物性状和全面了解基因功能至关重要。真核生物的基因表达调控可通过转录和表观遗传机制实现。在过去十年中，基因靶向技术的进步以及对表观遗传基因调控机制的进一步了解，极大地促进了可编程基因调控工具的发展。在这篇综述中，我们将讨论通过表观基因组编辑进行植物基因定向调控的最新进展，强调效应蛋白在通过 DNA 甲基化、组蛋白修饰和染色质重塑等不同机制调控目标基因表达方面的作用。此外，我们还将简要回顾植物中通过转录调控和 mRNA 修饰进行靶向基因调控的情况。
Targeted gene regulation through epigenome editing in plants
The precise targeted gene regulation in plants is essential for improving plant traits and gaining a comprehensive understanding of gene functions. The regulation of gene expression in eukaryotes can be achieved through transcriptional and epigenetic mechanisms. Over the last decade, advancements in gene-targeting technologies, along with an expanded understanding of epigenetic gene regulation mechanisms, have significantly contributed to the development of programmable gene regulation tools. In this review, we will discuss the recent progress in targeted plant gene regulation through epigenome editing, emphasizing the role of effector proteins in modulating target gene expression via diverse mechanisms, including DNA methylation, histone modifications, and chromatin remodeling. Additionally, we will also briefly review targeted gene regulation by transcriptional regulation and mRNA modifications in plants.
期刊介绍：
Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.
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