大鼠体内 Tradescantia spathacea 甲醇提取物的抗糖尿病和抗溃疡活性。

IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Syeda Shaheen Sultana, S Tasqeeruddin, Yahya I Asiri, Ns Murali Krishna, Syeda Nishath Sultana
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引用次数: 0

摘要

本研究旨在评估 Tradescantia spathacea 的抗糖尿病能力以及全草提取物的抗溃疡活性。使用链脲佐菌素口服葡萄糖耐量试验、糖尿病-阿洛桑和糖尿病模型对糖尿病状况进行了评估。在口服乙醇或幽门结扎引起胃溃疡的大鼠身上观察到了抗溃疡活性。标准物质包括雷尼替丁、格列本脲和琥珀酸盐。在所有模型中,使用试验提取物治疗的动物的血糖水平都明显低于糖尿病动物。同样,在所有模型中,接受试验提取物治疗的动物的溃疡指数都明显低于接受药物治疗的动物。我们的研究结果表明,T. Spathacea 提取物具有重要的抗糖尿病特性和抗溃疡特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antidiabetic and antiulcer activity of methanolic extract of Tradescantia spathacea in rats.

The present study was designed to assess Tradescantia spathacea's antidiabetic ability, as well as the antiulcer activity of the entire plant extract. The diabetic condition was evaluated using Streptozotocin's oral glucose tolerance test, diabetes-alloxan and diabetes-models. Antiulcer activities were observed in rats where gastric ulcers were either caused by oral administration of ethanol, or pyloric ligation. Standards include ranitidine, glibenclamide and sucralfate. In all models, the blood glucose levels of animals treated with the test extract were found to be significantly lower compared to diabetic care. Similarly, in all models, the ulcer index in the animals treated with the test extract was found to be significantly lower relative to the animals under vehicle supervision. Our findings say T. Spathacea extract has essential anti-diabetic properties, as well as antiulcer properties.

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来源期刊
CiteScore
1.40
自引率
12.50%
发文量
211
审稿时长
4.5 months
期刊介绍: Pakistan Journal of Pharmaceutical Sciences (PJPS) is a peer reviewed multi-disciplinary pharmaceutical sciences journal. The PJPS had its origin in 1988 from the Faculty of Pharmacy, University of Karachi as a biannual journal, frequency converted as quarterly in 2005, and now PJPS is being published as bi-monthly from January 2013. PJPS covers Biological, Pharmaceutical and Medicinal Research (Drug Delivery, Pharmacy Management, Molecular Biology, Biochemical, Pharmacology, Pharmacokinetics, Phytochemical, Bio-analytical, Therapeutics, Biotechnology and research on nano particles.
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