传染性疾病中 GBP 家族对炎症小体激活调控的研究进展。

Q3 Medicine

遗传 Pub Date : 2023-11-20 DOI:10.16288/j.yczz.23-119

Shu-Ting Quan, Wei-Wei Jiao, Fang Xu, Lin Sun, Hui Qi, Adong Shen

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引用次数: 0

摘要

鸟苷酸结合蛋白（GBPs）是干扰素诱导蛋白的一个亚家族，在细菌、病毒、衣原体和寄生虫感染中发挥着不同的作用。这些蛋白对传染病的进展和结果有着显著的影响。在宿主细胞自主免疫对抗病原体的领域中，GBPs 已被确定为通过规范和非规范炎性体激活途径进行热蛋白沉积的调节因子。在这篇综述中，我们总结了 GBP 家族成员的结构和进化、规范和非规范炎性体激活途径、GBPs 在调节炎性体激活中的作用以及 GBPs 影响不同病原体诱导的感染的机制。我们希望为感染性疾病的发病机制和诊断治疗提供新的基础研究线索。

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Advances in the regulation of inflammasome activation by GBP family in infectious diseases.

Guanylate-binding proteins (GBPs) are a subfamily of interferon-inducible proteins that undertake distinct roles in the the context of bacteria, virus, chlamydia and parasites infections. These proteins exert a notable influence on the progression and outcomes of infectious diseases. Within the realm of host cell-autonomous immunity against pathogens, GBPs have been identified as the regulators of pyroptosis through canonical and noncanonical inflammasome activation pathways. In this review, we summarize the structure and evolution of GBP family members, the canonical and noncanonical inflammasome activation pathways, the roles of GBPs in regulating inflammasome activation, and the mechanisms of GBPs affecting infections induced by different pathogens. We hope to provide new basic research clues for the pathogenesis and diagnosis and treatment of infectious diseases.

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来源期刊

遗传 Medicine-Medicine (all)

CiteScore

2.50

自引率

0.00%

发文量

6699

期刊介绍： Hereditas is a national academic journal sponsored by the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and the Chinese Society of Genetics and published by Science Press. It is a Chinese core journal and a Chinese high-quality scientific journal. The journal mainly publishes innovative research papers in the fields of genetics, genomics, cell biology, developmental biology, biological evolution, genetic engineering and biotechnology; new technologies and new methods; monographs and reviews on hot issues in the discipline; academic debates and discussions; experience in genetics teaching; introductions to famous geneticists at home and abroad; genetic counseling; information on academic conferences at home and abroad, etc. Main columns: review, frontier focus, research report, technology and method, resources and platform, experimental operation guide, genetic resources, genetics teaching, scientific news, etc.